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IRF-7 is the master regulator of type-I interferon-dependent immune responses
TLDR
It is shown that mice deficient in the Irf7 gene are more vulnerable than Myd88-/- mice to viral infection, and this correlates with a marked decrease in serum IFN levels, indicating the importance of the IRF-7-dependent induction of systemic IFN responses for innate antiviral immunity. Expand
DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response
TLDR
The artificial expression of otherwise IFN-inducible DAI (DLM-1/ZBP1) in mouse fibroblasts selectively enhances the DNA-mediated induction of type I IFN and other genes involved in innate immunity, and may offer new insight into the signalling mechanisms underlying DNA-associated antimicrobial immunity and autoimmune disorders. Expand
Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species
TLDR
Oral inoculation of Clostridium during the early life of conventionally reared mice resulted in resistance to colitis and systemic immunoglobulin E responses in adult mice, suggesting a new therapeutic approach to autoimmunity and allergy. Expand
Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors
TLDR
The transcription factor IRF-5 is identified as a new, principal downstream regulator of the TLR–MyD88 signalling pathway and a potential target of therapeutic intervention to control harmful immune responses. Expand
Spatiotemporal regulation of MyD88–IRF-7 signalling for robust type-I interferon induction
TLDR
Insight is offered into the regulation of TLR9 signalling in space, potentially suggesting a new avenue for therapeutic intervention in response toTLR9 activation. Expand
Activation of Rac and Cdc42 Video Imaged by Fluorescent Resonance Energy Transfer-Based Single-Molecule Probes in the Membrane of Living Cells
TLDR
Fluorescent resonance energy transfer-based probes which monitored the local balance between the activities of guanine nucleotide exchange factors and GTPase-activating proteins for Rac1 and Cdc42 at the membrane will accelerate the analysis of the spatiotemporal regulation of Rac and CDC42 in a living cell. Expand
Spatio-temporal images of growth-factor-induced activation of Ras and Rap1
TLDR
It is found that Ras at the neurites turned over rapidly; therefore, the sustained Ras activity at neurites was due to high GTP/GDP exchange rate and/or low GTPase activity, but not to the retention of the active Ras. Expand
Activity of Rho-family GTPases during cell division as visualized with FRET-based probes
TLDR
Two types of probes are added to monitor the activity balance between guanine nucleotide exchange factors and GTPase-activating proteins to visualize the complex spatio-temporal regulation of Rho-family GTPases during cell division. Expand
Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling.
TLDR
The complex defined in this study represents an example of how the coupling of the signaling adaptor and effector kinase molecules together with the transcription factor regulate the processing of an extracellular signal to evoke its versatile downstream transcriptional events in a cell. Expand
Negative regulation of Toll-like-receptor signaling by IRF-4.
TLDR
It is shown that IRF-4 also interacts with MyD88 and acts as a negative regulator of TLR signaling, which may provide an insight into the complex regulatory mechanisms of MyD 88 signaling by IRFs. Expand
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