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Progressive development of the rat osteoblast phenotype in vitro: Reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the…
The relationship of cell proliferation to the temporal expression of genes characterizing a developmental sequence associated with bone cell differentiation was examined in primary diploid cultures… Expand
Canonical WNT Signaling Promotes Osteogenesis by Directly Stimulating Runx2 Gene Expression*
- T. Gaur, C. Lengner, +8 authors J. Lian
- Biology, Medicine
- Journal of Biological Chemistry
- 30 September 2005
Both activating and null mutations of proteins required for canonical WNT signaling have revealed the importance of this pathway for normal skeletal development. However, tissue-specific… Expand
A microRNA signature for a BMP2-induced osteoblast lineage commitment program
- Zhaoyong Li, M. Q. Hassan, +5 authors G. Stein
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 16 September 2008
Bone morphogenetic proteins (BMPs) are potent morphogens that activate transcriptional programs for lineage determination. How BMP induction of a phenotype is coordinated with microRNAs (miRNAs) that… Expand
Molecular mechanisms mediating proliferation/differentiation interrelationships during progressive development of the osteoblast phenotype.
I. Introduction A FUNCTIONAL relationship between cell growth and the initiation and progression of events associated with differentiation has been a fundamental question challenging developmental… Expand
Self‐renewal of human embryonic stem cells is supported by a shortened G1 cell cycle phase
- Klaus A. Becker, P. Ghule, +4 authors G. Stein
- Biology, Medicine
- Journal of cellular physiology
- 1 December 2006
Competency for self‐renewal of human embryonic stem (ES) cells is linked to pluripotency. However, there is a critical paucity of fundamental parameters of human ES cell division. In this study we… Expand
Relationship of cell growth to the regulation of tissue‐specific gene expression during osteoblast differentiation
- G. Stein, J. Lian, T. Owen
- Biology, Medicine
- FASEB journal : official publication of the…
- 1 October 1990
The relationship of cell proliferation to the temporal expression of genes characterizing a developmental sequence associated with bone cell differentiation can be examined in primary diploid… Expand
Regulatory controls for osteoblast growth and differentiation: role of Runx/Cbfa/AML factors.
- J. Lian, A. Javed, +5 authors G. Stein
- Biology, Medicine
- Critical reviews in eukaryotic gene expression
- 2004
Formation of skeletal elements during embryogenesis and the dynamic remodeling of bone in the adult involve an exquisite interplay of developmental cues, signaling proteins, transcription factors,… Expand
A program of microRNAs controls osteogenic lineage progression by targeting transcription factor Runx2
- Y. Zhang, R. Xie, +4 authors G. Stein
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 31 May 2011
Lineage progression in osteoblasts and chondrocytes is stringently controlled by the cell-fate–determining transcription factor Runx2. In this study, we directly addressed whether microRNAs (miRNAs)… Expand
Networks and hubs for the transcriptional control of osteoblastogenesis
- J. Lian, G. Stein, +7 authors D. Young
- Biology, Medicine
- Reviews in Endocrine and Metabolic Disorders
- 19 October 2006
We present an overview of the concepts of tissue-specific transcriptional control mechanisms essential for development of the bone cell phenotype. BMP2 induced transcription factors constitute a… Expand
Osteoblast differentiation and skeletal development are regulated by Mdm2–p53 signaling
- C. Lengner, Heather A. Steinman, +6 authors S. Jones
- Biology, Medicine
- The Journal of cell biology
- 13 March 2006
Mdm2 is required to negatively regulate p53 activity at the peri-implantation stage of early mouse development. However, the absolute requirement for Mdm2 throughout embryogenesis and in… Expand