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Progressive development of the rat osteoblast phenotype in vitro: Reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the
The relationship of cell proliferation to the temporal expression of genes characterizing a developmental sequence associated with bone cell differentiation was examined in primary diploid culturesExpand
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Canonical WNT Signaling Promotes Osteogenesis by Directly Stimulating Runx2 Gene Expression*
Both activating and null mutations of proteins required for canonical WNT signaling have revealed the importance of this pathway for normal skeletal development. However, tissue-specificExpand
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A microRNA signature for a BMP2-induced osteoblast lineage commitment program
Bone morphogenetic proteins (BMPs) are potent morphogens that activate transcriptional programs for lineage determination. How BMP induction of a phenotype is coordinated with microRNAs (miRNAs) thatExpand
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Molecular mechanisms mediating proliferation/differentiation interrelationships during progressive development of the osteoblast phenotype.
I. Introduction A FUNCTIONAL relationship between cell growth and the initiation and progression of events associated with differentiation has been a fundamental question challenging developmentalExpand
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Self‐renewal of human embryonic stem cells is supported by a shortened G1 cell cycle phase
Competency for self‐renewal of human embryonic stem (ES) cells is linked to pluripotency. However, there is a critical paucity of fundamental parameters of human ES cell division. In this study weExpand
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Relationship of cell growth to the regulation of tissue‐specific gene expression during osteoblast differentiation
The relationship of cell proliferation to the temporal expression of genes characterizing a developmental sequence associated with bone cell differentiation can be examined in primary diploidExpand
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Regulatory controls for osteoblast growth and differentiation: role of Runx/Cbfa/AML factors.
Formation of skeletal elements during embryogenesis and the dynamic remodeling of bone in the adult involve an exquisite interplay of developmental cues, signaling proteins, transcription factors,Expand
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A program of microRNAs controls osteogenic lineage progression by targeting transcription factor Runx2
  • Y. Zhang, R. Xie, +4 authors G. Stein
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 31 May 2011
Lineage progression in osteoblasts and chondrocytes is stringently controlled by the cell-fate–determining transcription factor Runx2. In this study, we directly addressed whether microRNAs (miRNAs)Expand
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Networks and hubs for the transcriptional control of osteoblastogenesis
We present an overview of the concepts of tissue-specific transcriptional control mechanisms essential for development of the bone cell phenotype. BMP2 induced transcription factors constitute aExpand
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Osteoblast differentiation and skeletal development are regulated by Mdm2–p53 signaling
Mdm2 is required to negatively regulate p53 activity at the peri-implantation stage of early mouse development. However, the absolute requirement for Mdm2 throughout embryogenesis and inExpand
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