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DNA vaccines: protective immunizations by parenteral, mucosal, and gene-gun inoculations.
Plasmid DNAs expressing influenza virus hemagglutinin glycoproteins have been tested for their ability to raise protective immunity against lethal influenza challenges of the same subtype. In trialsExpand
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Different T helper cell types and antibody isotypes generated by saline and gene gun DNA immunization.
Several routes and methods of DNA immunization have been shown to generate Ab, Th cells, and CTL responses. However, few studies have directly compared the immune responses generated by differentExpand
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Control of a Mucosal Challenge and Prevention of AIDS by a Multiprotein DNA/MVA Vaccine
Heterologous prime/boost regimens have the potential for raising high levels of immune responses. Here we report that DNA priming followed by a recombinant modified vaccinia Ankara (rMVA) boosterExpand
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Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine.
Heterologous prime/boost regimens have the potential for raising high levels of immune responses. Here we report that DNA priming followed by a recombinant modified vaccinia Ankara (rMVA) boosterExpand
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Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine.
Heterologous prime/boost regimens have the potential for raising high levels of immune responses. Here, we report that DNA priming followed by a recombinant modified vaccinia Ankara (rMVA) boosterExpand
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Multiple-Cytokine-Producing Antiviral CD4 T Cells Are Functionally Superior to Single-Cytokine-Producing Cells
ABSTRACT Virus-specific CD4 T cells are endowed with multiple functions, such as cytokine production, CD40 ligand (CD40L) expression (associated with the costimulation of CD8 and B cells), andExpand
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Protection against a lethal influenza virus challenge by immunization with a haemagglutinin-expressing plasmid DNA.
Direct DNA inoculations have been used to demonstrate that in vivo transfections can be used to elicit protective immune responses. The direct inoculation of an H7 haemagglutinin-expressing DNAExpand
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Phase 1 safety and immunogenicity testing of DNA and recombinant modified vaccinia Ankara vaccines expressing HIV-1 virus-like particles.
BACKGROUND Recombinant DNA and modified vaccinia virus Ankara (rMVA) vaccines represent a promising approach to an HIV/AIDS vaccine. This Phase 1 clinical trial compared the safety and immunogenicityExpand
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Selenodiglutathione is a highly efficient oxidant of reduced thioredoxin and a substrate for mammalian thioredoxin reductase
After printing the PDF file (use normal quality), please read the page proofs carefully and: 1) indicate changes or corrections in the margin of the page proofs; 2) answer all queries (footnotesExpand
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DNA vaccines.
What is a DNA vaccine? A DNA vaccine uses a gene from a virus or bacteria to stimulate the immune system. When the DNA vaccine is administered to a patient, the machinery in their cells makes a viralExpand
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