Interferon Regulatory Factor 1

Known as: Transcription Factor, IREBF1, Interferon Stimulated Gene Factor 1, IRF-1 Protein 
An interferon regulatory factor that binds upstream TRANSCRIPTIONAL REGULATORY ELEMENTS in the GENES for INTERFERON-ALPHA and INTERFERON-BETA. It… (More)
National Institutes of Health

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IRF1 geneIRF1 wt AlleleIn BloodProcess of secretion
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IRF1 protein, human

Papers overview

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2010
2010
Activation of IL-27 p28 gene transcription by interferon regulatory factor 8 in cooperation with interferon regulatory factor 1.
Interferon regulatory factor (IRF) family members, especially interferon regulatory factor-1 (IRF-1) and interferon regulatory… (More)
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Highly Cited
2006
Highly Cited
2006
Interferon regulatory factor-1 is prerequisite to the constitutive expression and IFN-gamma-induced upregulation of B7-H1 (CD274).
Majority of cancer cells upregulate co-inhibitory molecule B7-H1 which confers resistance to anti-tumor immunity, allowing… (More)
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2006
2006
Interferon regulatory factor 8 regulates RANTES gene transcription in cooperation with interferon regulatory factor-1, NF-kappaB, and PU.1.
Interferon regulatory factor (IRF)-8 is a member of the IRF family of transcription factors important in interferon-gamma… (More)
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2001
2001
Ectopic expression of interferon regulatory factor-1 potentiates granulocytic differentiation.
Numerous transcription factors allow haematopoietic cells to respond to lineage- and stage-specific cytokines and to act as their… (More)
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Review
2001
Review
2001
Stimulation of interferon regulatory factor-1 by prolactin.
Prolactin (PRL), a pituitary peptide hormone, is known to regulate diverse cellular functions including proliferation… (More)
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Highly Cited
1997
Highly Cited
1997
Synergy between interferon-gamma and tumor necrosis factor-alpha in transcriptional activation is mediated by cooperation between signal transducer and activator of transcription 1 and nuclear factor…
Interferon-gamma (IFNgamma) and tumor necrosis factor-alpha (TNFalpha) cooperate to induce the expression of many gene products… (More)
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Highly Cited
1996
Highly Cited
1996
Retinoic acid activates interferon regulatory factor-1 gene expression in myeloid cells.
All-trans-retinoic acid (ATRA) is the drug of choice in the treatment of acute promyelocytic leukemia (APL). ATRA induces both in… (More)
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Highly Cited
1994
Highly Cited
1994
Structure and regulation of the human interferon regulatory factor 1 (IRF-1) and IRF-2 genes: implications for a gene network in the interferon system.
Interferon regulatory factor 1 (IRF-1) and IRF-2 are structurally similar DNA-binding factors which were originally identified as… (More)
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Highly Cited
1993
Highly Cited
1993
Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development
Interferon regulatory factor 1 (IRF-1), a transcriptional activator, and its antagonistic repressor, IRF-2, were originally… (More)
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Highly Cited
1988
Highly Cited
1988
Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements
Expression of the interferon-beta (IFN-beta) gene is induced by a variety of agents, including viruses. Evidence has been… (More)
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