The first exon of the human sc gene contains an androgen responsive unit and an interferon regulatory factor element

@article{Haelens1999TheFE,
  title={The first exon of the human sc gene contains an androgen responsive unit and an interferon regulatory factor element},
  author={Annemie Haelens and Guy Verrijdt and E. Schoenmakers and Philippe Alen and Frank Claessens},
  journal={Molecular and Cellular Endocrinology},
  year={1999},
  volume={153},
  pages={91-102}
}
Secretory component (SC) plays a key role in the transport of IgA and IgM to the lumina of many glands. The gene is constitutively expressed, but can be modulated by hormonal and immunological stimuli. Recently, the promoter and the first exon of the human sc gene have been cloned. The first exon contains a putative androgen/glucocorticoid response element (ARE/GRE) and an Interferon Regulatory Factor Element (IRF-E). Here we show that the ARE/GRE can bind the DNA-binding domain (DBD) of both… CONTINUE READING

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