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The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling
TLDR
A novel function for MAD-related proteins as intracellular antagonists of the type I kinase domain of TGFβ family receptors is defined as blocking the association, phosphorylation, and activation of Smad2. Expand
The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling.
TLDR
A novel function for MAD-related proteins as intracellular antagonists of the type I kinase domain of TGFbeta family receptors is defined as blocking the association, phosphorylation, and activation of Smad2. Expand
Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins.
TLDR
Endothelial leukocyte adhesion molecule-1 (ELAM-1), a cell surface glycoprotein expressed by cytokine-activated endothelium, mediates the adhesion of blood neutrophils and may be a member of a nascent gene family of cell surface molecules involved in the regulation of inflammatory and immunological events at the interface of vessel wall and blood. Expand
Identification of an inducible endothelial-leukocyte adhesion molecule.
The accumulation of blood leukocytes at sites of inflammation depends upon their localized adhesion to the vascular lining. We have investigated the hypothesis that this adhesive interaction involvesExpand
Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2.
TLDR
KLF2 therefore serves as a mechano-activated transcription factor important in the integration of multiple endothelial functions associated with regions of the arterial vasculature that are relatively resistant to atherogenesis. Expand
KLF2 Is a Novel Transcriptional Regulator of Endothelial Proinflammatory Activation
TLDR
The studies implicate recruitment by KLF2 of the transcriptional coactivator cyclic AMP response element–binding protein (CBP/p300) as a unifying mechanism for these various effects of proinflammatory stimuli. Expand
Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines.
TLDR
It is proposed that nitric oxide's ability to limit endothelial activation and inhibit monocyte adhesion may contribute to some of its antiatherogenic and antiinflammatory properties within the vessel wall. Expand
MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions
TLDR
It is concluded that chemokines are important modulators of monocyte–endothelial interactions under flow conditions and the finding that IL-8 is a powerful trigger for firm adhesion of monocytes to vascular endothelium reveals an unexpected role for this chemokine in monocyte recruitment. Expand
Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon.
We have used the quantitative binding of murine monoclonal antibodies to the surface of cultured human umbilical vein endothelial (HUVE) cells to study the responses of HUVE cells to three differentExpand
Future research directions in acute lung injury: summary of a National Heart, Lung, and Blood Institute working group.
TLDR
Improved understanding of disease heterogeneity through use of evolving biologic, genomic, and genetic approaches should provide major new insights into pathogenesis of ALI. Expand
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