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T Helper Cell Type 2 Cytokine–Mediated Comitogenic Responses and Ccr3 Expression during Differentiation of Human Mast Cells in Vitro
HMCs obey SCF-dependent, cytokine-driven mitogenic responses that reflect a Th2-type polarization characteristic of allergy and asthma and have a unique profile of chemokine receptor expression from among reported hematopoietic cells. Expand
Quantitative immunohistochemical determination of 8-hydroxy-2'-deoxyguanosine by a monoclonal antibody N45.1: its application to ferric nitrilotriacetate-induced renal carcinogenesis model.
The present method has advantages over the high-performance liquid Chromatography/electrochemical detector, gas chromatography/mass spectrometry, and 32P-postlabeling methods in that it allows localization of 8-OHdG to be specified without the risk of artifactual production of 8 -OHdGs during the DNA extraction and hydrolytic processes. Expand
Biomarker evidence of DNA oxidation in lung cancer patients: association of urinary 8‐hydroxy‐2′‐deoxyguanosine excretion with radiotherapy, chemotherapy, and response to treatment
Ratios of urinary 8‐hydroxy‐2′‐deoxyguanosine to urinary creatinine (8‐OHdG/creatinine) have been considered as a good biological indicator of DNA oxidation and found an increase in non‐small‐cell carcinoma patients during the course of radiotherapy and chemotherapy. Expand
New biomarker evidence of oxidative DNA damage in patients with non‐insulin‐dependent diabetes mellitus
The increased excretion of urinary 8‐OHdG is seen as indicating an increased systemic level of oxidative DNA damage in NIDDM patients. Expand
Human Mast Cell Progenitors Can Be Infected by Macrophagetropic Human Immunodeficiency Virus Type 1 and Retain Virus with Maturation In Vitro
The trafficking of mast cell progenitors to multiple tissues, combined with the long life span of mature mast cells, suggests that they could provide a widespread and persistent HIV reservoir in AIDS. Expand
Inhibitory activity on bacterial motility and in vivo protective activity of human monoclonal antibodies against flagella of Pseudomonas aeruginosa
Three stable hybridoma cell lines, IN-2A8, IN-5D6, and ZI-3A8, that secrete human monoclonal antibodies (MAbs) specific for b-type flagella of Pseudomonas aeruginosa were established by fusingExpand
Intranuclear Distribution of 8-hydroxy-2'-deoxyguanosine: An Immunocytochemical Study
The results suggest that specific nuclear sites are vulnerable to oxidative DNA damage and that diffuse intense signals precede cell death after oxidative stress. Expand
Leukocyte function-associated antigen-1 expression on decidual natural killer cells in patients with early pregnancy loss.
The results indicate that up-regulation of LFA-1 on CD56(bright) NK cells is related to spontaneous abortion or the onset of menstruation. Expand
Effects of a human antiflagellar monoclonal antibody in combination with antibiotics on Pseudomonas aeruginosa infection
The results suggest that an antiflagellar monoclonal antibody would be effective against systemic infection in combination with some kinds of antibiotics. Expand
Progesterone and estrogen receptors in Japanese breast cancer.
Assays of ER and/or PgR are useful markers for predicting response to endocrine therapy in breast cancer patients, suggesting that in some breast cancers the synthesis of PGR depends on the action of estrogens. Expand