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IRF1 gene

Known as: interferon regulatory factor-1, Interferon Regulatory Factor 1 Gene, MAR 
This gene plays a role in the transcriptional activation of target genes. It is also involved in promoting apoptosis.
National Institutes of Health

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ApoptosisHomo sapiensIRF1 protein, humanInterferon Regulatory Factor 1

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IRF1 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
A variant of DC-SIGN gene promoter associated with resistance to HIV-1 in serodiscordant couples in Burkina Faso.
2012
2012
Toll-Like Receptor 3 and Suppressor of Cytokine Signaling Proteins Regulate CXCR4 and CXCR7 Expression in Bone Marrow-Derived Human Multipotent Stromal Cells
Background The use of bone marrow-derived human multipotent stromal cells (hMSC) in cell-based therapies has dramatically… 
2007
2007
The A4396G polymorphism in interferon regulatory factor 1 is frequently expressed in breast cancer cell lines.
2007
2007
STAT1-independent inhibition of cyclooxygenase-2 expression by IFNγ; a common pathway of IFNγ-mediated gene repression but not gene activation
Cyclooxygenase-2 (COX-2), the rate-limiting enzyme in the synthesis of prostaglandins, promotes the development of colorectal… 
2007
2007
STAT1-independent inhibition of cyclooxygenase-2 expression by IFNgamma; a common pathway of IFNgamma-mediated gene repression but not gene activation.
Cyclooxygenase-2 (COX-2), the rate-limiting enzyme in the synthesis of prostaglandins, promotes the development of colorectal… 
2004
2004
Novel interferon regulatory factor-1 polymorphisms in a Kenyan population revealed by complete gene sequencing
AbstractVariation in susceptibility to HIV-1 infection depends on numerous factors, and host genetic variation has been well… 
Highly Cited
1998
Highly Cited
1998
Synergistic stimulation of MHC class I and IRF‐1 gene expression by IFN‐γ and TNF‐α in oligodendrocytes
In order to understand the molecular basis of the synergistic action of interferon γ (IFN‐γ) and tumour necrosis factor α (TNF… 
1998
1998
Association study of asthma and atopy traits and chromosome 5q cytokine cluster markers
Linkage studies have provided evidence for the presence of gene(s) in the 5q cytokine cluster region which control total serum… 
1997
1997
Interferon regulatory factor 1 induces the expression of the interferon‐stimulated genes
The interferon regulatory factor 1 (IRF‐1) is a positive transcriptional regulatory protein which acts in the interferon signal… 
Highly Cited
1992
Highly Cited
1992
The selective isolation of novel cDNAs encoded by the regions surrounding the human interleukin 4 and 5 genes.
We have developed modifications to direct cDNA selection that allow the rapid and reproducible isolation of low abundance cDNAs… 
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