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IRF1 gene

Known as: interferon regulatory factor-1, Interferon Regulatory Factor 1 Gene, MAR 
This gene plays a role in the transcriptional activation of target genes. It is also involved in promoting apoptosis.
National Institutes of Health

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ApoptosisHomo sapiensIRF1 protein, humanInterferon Regulatory Factor 1
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IRF1 wt Allele

Papers overview

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Highly Cited
2002
Highly Cited
2002
Opposing roles of STAT1 and STAT3 in T cell-mediated hepatitis: regulation by SOCS.
T cell-mediated fulminant hepatitis is a life-threatening event for which the underlying mechanism is not fully understood… Expand
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Highly Cited
2000
Highly Cited
2000
How Stat1 mediates constitutive gene expression: a complex of unphosphorylated Stat1 and IRF1 supports transcription of the LMP2 gene
Analysis of mRNA levels in cells that express or lack signal transducers and activators of transcription 1 (Stat1) reveals that… Expand
Highly Cited
1999
Highly Cited
1999
Two Distinct Gamma Interferon-Inducible Promoters of the Major Histocompatibility Complex Class II Transactivator Gene Are Differentially Regulated by STAT1, Interferon Regulatory Factor 1, and…
ABSTRACT The major histocompatibility complex (MHC) class II transactivator (CIITA) is the master regulatory factor required for… Expand
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Highly Cited
1998
Highly Cited
1998
PU.1, Interferon Regulatory Factor 1, and Interferon Consensus Sequence-binding Protein Cooperate to Increase gp91 phox Expression*
gp91 phox is a subunit of the phagocyte respiratory burst oxidase catalytic unit. Transcription ofCYBB, the gene encoding gp91… Expand
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Highly Cited
1994
Highly Cited
1994
Structure and regulation of the human interferon regulatory factor 1 (IRF-1) and IRF-2 genes: implications for a gene network in the interferon system.
Interferon regulatory factor 1 (IRF-1) and IRF-2 are structurally similar DNA-binding factors which were originally identified as… Expand
Highly Cited
1994
Highly Cited
1994
Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation.
Interferon regulation of gene expression is dependent on the tyrosine phosphorylation and activation of the DNA-binding activity… Expand
Highly Cited
1994
Highly Cited
1994
Mice devoid of interferon regulatory factor 1 (IRF‐1) show normal expression of type I interferon genes.
The transcription factor interferon regulatory factor 1 (IRF‐1) binds tightly to the interferon (IFN)‐beta promoter and has been… Expand
Highly Cited
1993
Highly Cited
1993
Recognition DNA sequences of interferon regulatory factor 1 (IRF-1) and IRF-2, regulators of cell growth and the interferon system.
Interferon (IFN) regulatory factor 1 (IRF-1) and IRF-2 were originally identified as transcription factors involved in the… Expand
Highly Cited
1993
Highly Cited
1993
A novel interferon-inducible domain: structural and functional analysis of the human interferon regulatory factor 1 gene promoter.
We have cloned and functionally characterized the human interferon regulatory factor 1 (IRF-1) gene promoter. The promoter… Expand
Highly Cited
1991
Highly Cited
1991
Interferon regulatory factor 1 is a myeloid differentiation primary response gene induced by interleukin 6 and leukemia inhibitory factor: role in growth inhibition.
To better understand the immediate early genetic response of myeloid cells to terminal differentiation and growth inhibitory… Expand
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