FAQ

IRF1 gene

Known as: interferon regulatory factor-1, Interferon Regulatory Factor 1 Gene, MAR 
This gene plays a role in the transcriptional activation of target genes. It is also involved in promoting apoptosis.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1988-2017
0102019882017

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8 relations
ApoptosisHomo sapiensIRF1 protein, humanInterferon Regulatory Factor 1
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IRF1 wt Allele

Related mentions per year

Related mentions per year

1936-2019
19401960198020002020
IRF1 gene
Apoptosis
Stomach Carcinoma
Homo sapiens
Transcriptional Regulation
IRF1 protein, human

Papers overview

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Highly Cited
2011
Highly Cited
2011
A diverse range of gene products are effectors of the type I interferon antiviral response.
The type I interferon response protects cells against invading viral pathogens. The cellular factors that mediate this defence… (More)
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2010
2010
Downregulation of microRNA-383 is associated with male infertility and promotes testicular embryonal carcinoma cell proliferation by targeting IRF1
Our previous studies have shown that microRNA-383 (miR-383) expression is downregulated in the testes of infertile men with… (More)
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Highly Cited
2006
Highly Cited
2006
Interferon regulatory factor-1 is prerequisite to the constitutive expression and IFN-gamma-induced upregulation of B7-H1 (CD274).
Majority of cancer cells upregulate co-inhibitory molecule B7-H1 which confers resistance to anti-tumor immunity, allowing… (More)
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2005
2005
Interferon regulatory factor-1 (IRF-1) exhibits tumor suppressor activities in breast cancer associated with caspase activation and induction of apoptosis.
We have directly assessed the ability of interferon regulatory factor-1 (IRF-1) to act as a tumor suppressor gene in human breast… (More)
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Highly Cited
2000
Highly Cited
2000
Inactivation of interferon regulatory factor-1 tumor suppressor protein by HPV E7 oncoprotein. Implication for the E7-mediated immune evasion mechanism in cervical carcinogenesis.
In studying biological roles of interferon regulatory factor (IRF)-1 tumor suppressor in cervical carcinogenesis, we found that… (More)
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Highly Cited
2000
Highly Cited
2000
Inflammation influences vascular remodeling through AT2 receptor expression and signaling.
The AT(2) receptor, which exerts growth inhibitory effects in cell culture, is present scantily in the adult vasculature but is… (More)
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Highly Cited
1999
Highly Cited
1999
Interaction of interferon regulatory factor-1 and nuclear factor kappaB during activation of inducible nitric oxide synthase transcription.
We investigated the molecular mechanism for the synergistic induction of inducible nitric oxide synthase transcription by TNF… (More)
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Highly Cited
1996
Highly Cited
1996
Retinoic acid activates interferon regulatory factor-1 gene expression in myeloid cells.
All-trans-retinoic acid (ATRA) is the drug of choice in the treatment of acute promyelocytic leukemia (APL). ATRA induces both in… (More)
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Highly Cited
1988
Highly Cited
1988
Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-beta gene regulatory elements.
Expression of the interferon-beta (IFN-beta) gene is induced by a variety of agents, including viruses. Evidence has been… (More)
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Highly Cited
1988
Highly Cited
1988
Evidence for a nuclear factor(s), IRF-1, mediating induction and silencing properties to human IFN-beta gene regulatory elements.
Transcription of the human interferon-beta (IFN-beta) gene is induced by a variety of agents such as viruses, dsRNA and some… (More)
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