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IRF1 gene

Known as: interferon regulatory factor-1, Interferon Regulatory Factor 1 Gene, MAR 
This gene plays a role in the transcriptional activation of target genes. It is also involved in promoting apoptosis.
National Institutes of Health

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ApoptosisHomo sapiensIRF1 protein, humanInterferon Regulatory Factor 1
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IRF1 wt Allele

Papers overview

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2015
2015
IFN-γ-mediated IRF1/miR-29b feedback loop suppresses colorectal cancer cell growth and metastasis by repressing IGF1.
To investigate the clinicopathological significance and underlying mechanism of microRNA-29b (miR-29b) in colorectal cancer (CRC… Expand
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2011
2011
Transcriptional repression of C4 complement by hepatitis C virus proteins.
The fourth component of human complement (C4) plays an important role in innate immune function. C4 activity has been observed to… Expand
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Highly Cited
2005
Highly Cited
2005
SUMO-1 conjugation selectively modulates STAT1-mediated gene responses.
Signal transducers and activators of transcription 1 (STAT1) is a critical mediator of interferon (IFN)-induced gene responses… Expand
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2003
2003
IL12B and IRF1 gene polymorphisms and susceptibility to celiac disease.
Celiac disease (CD) is a common gastro-intestinal disorder resulting from permanent intolerance to wheat gliadins and related… Expand
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Highly Cited
2002
Highly Cited
2002
Opposing roles of STAT1 and STAT3 in T cell-mediated hepatitis: regulation by SOCS.
T cell-mediated fulminant hepatitis is a life-threatening event for which the underlying mechanism is not fully understood… Expand
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Highly Cited
2000
Highly Cited
2000
How Stat1 mediates constitutive gene expression: a complex of unphosphorylated Stat1 and IRF1 supports transcription of the LMP2 gene.
Analysis of mRNA levels in cells that express or lack signal transducers and activators of transcription 1 (Stat1) reveals that… Expand
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1998
1998
Synergistic stimulation of MHC class I and IRF-1 gene expression by IFN-gamma and TNF-alpha in oligodendrocytes.
In order to understand the molecular basis of the synergistic action of interferon gamma (IFN-gamma) and tumour necrosis factor… Expand
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1997
1997
Transcriptional inhibition by Stat5. Differential activities at growth-related versus differentiation-specific promoters.
Prolactin (PRL) induces transcriptional activation of not only growth-related genes such as interferon regulatory factor-1 (IRF-1… Expand
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Highly Cited
1994
Highly Cited
1994
Structure and regulation of the human interferon regulatory factor 1 (IRF-1) and IRF-2 genes: implications for a gene network in the interferon system.
Interferon regulatory factor 1 (IRF-1) and IRF-2 are structurally similar DNA-binding factors which were originally identified as… Expand
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Highly Cited
1993
Highly Cited
1993
Recognition DNA sequences of interferon regulatory factor 1 (IRF-1) and IRF-2, regulators of cell growth and the interferon system.
Interferon (IFN) regulatory factor 1 (IRF-1) and IRF-2 were originally identified as transcription factors involved in the… Expand
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