IRF1 gene

Known as: interferon regulatory factor-1, Interferon Regulatory Factor 1 Gene, MAR 
This gene plays a role in the transcriptional activation of target genes. It is also involved in promoting apoptosis.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1988-2017
0102019882017

Papers overview

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Highly Cited
2011
Highly Cited
2011
The type I interferon response protects cells against invading viral pathogens. The cellular factors that mediate this defence… (More)
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2010
2010
Our previous studies have shown that microRNA-383 (miR-383) expression is downregulated in the testes of infertile men with… (More)
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Highly Cited
2006
Highly Cited
2006
Majority of cancer cells upregulate co-inhibitory molecule B7-H1 which confers resistance to anti-tumor immunity, allowing… (More)
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2005
2005
We have directly assessed the ability of interferon regulatory factor-1 (IRF-1) to act as a tumor suppressor gene in human breast… (More)
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Highly Cited
2000
Highly Cited
2000
In studying biological roles of interferon regulatory factor (IRF)-1 tumor suppressor in cervical carcinogenesis, we found that… (More)
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Highly Cited
2000
Highly Cited
2000
The AT(2) receptor, which exerts growth inhibitory effects in cell culture, is present scantily in the adult vasculature but is… (More)
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Highly Cited
1999
Highly Cited
1999
We investigated the molecular mechanism for the synergistic induction of inducible nitric oxide synthase transcription by TNF… (More)
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Highly Cited
1996
Highly Cited
1996
All-trans-retinoic acid (ATRA) is the drug of choice in the treatment of acute promyelocytic leukemia (APL). ATRA induces both in… (More)
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Highly Cited
1988
Highly Cited
1988
Expression of the interferon-beta (IFN-beta) gene is induced by a variety of agents, including viruses. Evidence has been… (More)
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Highly Cited
1988
Highly Cited
1988
Transcription of the human interferon-beta (IFN-beta) gene is induced by a variety of agents such as viruses, dsRNA and some… (More)
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