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IRF1 gene
Known as:
interferon regulatory factor-1
, Interferon Regulatory Factor 1 Gene
, MAR
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This gene plays a role in the transcriptional activation of target genes. It is also involved in promoting apoptosis.
National Institutes of Health
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Related topics
Related topics
8 relations
Apoptosis
Homo sapiens
IRF1 protein, human
Interferon Regulatory Factor 1
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IRF1 wt Allele
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2002
Highly Cited
2002
Opposing roles of STAT1 and STAT3 in T cell-mediated hepatitis: regulation by SOCS.
F. Hong
,
B. Jaruga
,
+5 authors
B. Gao
The Journal of clinical investigation
2002
Corpus ID: 28579663
T cell-mediated fulminant hepatitis is a life-threatening event for which the underlying mechanism is not fully understood…
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Highly Cited
2000
Highly Cited
2000
How Stat1 mediates constitutive gene expression: a complex of unphosphorylated Stat1 and IRF1 supports transcription of the LMP2 gene
M. Chatterjee‐Kishore
,
K. Wright
,
J. Ting
,
G. Stark
The EMBO journal
2000
Corpus ID: 29703239
Analysis of mRNA levels in cells that express or lack signal transducers and activators of transcription 1 (Stat1) reveals that…
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Highly Cited
2000
Highly Cited
2000
Interaction of pseudomonas aeruginosa with epithelial cells: identification of differentially regulated genes by expression microarray analysis of human cDNAs.
J. Ichikawa
,
A. Norris
,
+4 authors
S. Lory
Proceedings of the National Academy of Sciences…
2000
Corpus ID: 39235034
Pseudomonas aeruginosa is an opportunistic pathogen that plays a major role in lung function deterioration in cystic fibrosis…
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Highly Cited
1999
Highly Cited
1999
Two Distinct Gamma Interferon-Inducible Promoters of the Major Histocompatibility Complex Class II Transactivator Gene Are Differentially Regulated by STAT1, Interferon Regulatory Factor 1, and…
J. Piskurich
,
M. Linhoff
,
Ying Wang
,
J. Ting
Molecular and Cellular Biology
1999
Corpus ID: 25188255
ABSTRACT The major histocompatibility complex (MHC) class II transactivator (CIITA) is the master regulatory factor required for…
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Highly Cited
1998
Highly Cited
1998
PU.1, Interferon Regulatory Factor 1, and Interferon Consensus Sequence-binding Protein Cooperate to Increase gp91 phox Expression*
E. Eklund
,
A. Jalava
,
R. Kakar
The Journal of Biological Chemistry
1998
Corpus ID: 35058296
gp91 phox is a subunit of the phagocyte respiratory burst oxidase catalytic unit. Transcription ofCYBB, the gene encoding gp91…
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Highly Cited
1994
Highly Cited
1994
Structure and regulation of the human interferon regulatory factor 1 (IRF-1) and IRF-2 genes: implications for a gene network in the interferon system.
H. Harada
,
E. Takahashi
,
S. Itoh
,
K. Harada
,
T. Hori
,
T. Taniguchi
Molecular and cellular biology
1994
Corpus ID: 43469122
Interferon regulatory factor 1 (IRF-1) and IRF-2 are structurally similar DNA-binding factors which were originally identified as…
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Highly Cited
1994
Highly Cited
1994
Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation.
K. Yamamoto
,
F. Quelle
,
+6 authors
J. Ihle
Molecular and cellular biology
1994
Corpus ID: 40965123
Interferon regulation of gene expression is dependent on the tyrosine phosphorylation and activation of the DNA-binding activity…
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Highly Cited
1993
Highly Cited
1993
Recognition DNA sequences of interferon regulatory factor 1 (IRF-1) and IRF-2, regulators of cell growth and the interferon system
N. Tanaka
,
T. Kawakami
,
T. Taniguchi
Molecular and cellular biology
1993
Corpus ID: 22913651
Interferon (IFN) regulatory factor 1 (IRF-1) and IRF-2 were originally identified as transcription factors involved in the…
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Highly Cited
1993
Highly Cited
1993
A novel interferon-inducible domain: structural and functional analysis of the human interferon regulatory factor 1 gene promoter.
S. Sims
,
Y. Cha
,
M. Romine
,
P. Gao
,
K. Gottlieb
,
A. Deisseroth
Molecular and cellular biology
1993
Corpus ID: 2460405
We have cloned and functionally characterized the human interferon regulatory factor 1 (IRF-1) gene promoter. The promoter…
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Highly Cited
1991
Highly Cited
1991
Interferon regulatory factor 1 is a myeloid differentiation primary response gene induced by interleukin 6 and leukemia inhibitory factor: role in growth inhibition.
A. Abdollahi
,
K. Lord
,
B. Hoffman‐Liebermann
,
D. Liebermann
Cell growth & differentiation : the molecular…
1991
Corpus ID: 29121708
To better understand the immediate early genetic response of myeloid cells to terminal differentiation and growth inhibitory…
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