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Insulin Receptor Substrate-2 Protein

Known as: Insulin Receptor Substrate 2, Insulin Receptor Substrate 2 Protein, Insulin Receptor Substrate-2 
 
National Institutes of Health

Related topics

Related topics

3 relations
IRS2 gene

Narrower (1)

IRS2 protein, human

Broader (1)

Insulin Receptor Substrate Proteins

Papers overview

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Highly Cited
2011
Highly Cited
2011
Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2
Mice overexpressing acylCoA:diacylglycerol (DAG) acyltransferase 2 in the liver (Liv-DGAT2) have been shown to have normal… Expand
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Highly Cited
2008
Highly Cited
2008
Response to Comment on "Brain IRS2 Signaling Coordinates Life Span and Nutrient Homeostasis"
Differences in reported life span of mice heterozygous for a null allele of the insulin receptor substrate–2 (Irs2) might involve… Expand
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Review
2008
Review
2008
Untangling the Complex Web of IL-4– and IL-13–Mediated Signaling Pathways
Understanding how IL-4 and IL-13 signaling differ could result in the development of better anti-inflammatory therapies… Expand
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Highly Cited
2007
Highly Cited
2007
The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas
We analyzed the PI3K-AKT signaling cascade in a cohort of sarcomas and found a marked induction of insulin receptor substrate-2… Expand
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Highly Cited
2003
Highly Cited
2003
Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes.
The insulin receptor substrate-2 (Irs2) branch of the insulin/IGF signaling system coordinates peripheral insulin action and… Expand
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Highly Cited
2002
Highly Cited
2002
The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth.
Diabetes is caused by an absolute (type 1) or relative (type 2) deficiency of insulin-producing beta cells. The mechanisms… Expand
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Highly Cited
2002
Highly Cited
2002
β cell expression of IGF-I leads to recovery from type 1 diabetes
Patients with type 1 diabetes are identified after the onset of the disease, when β cell destruction is almost complete. β cell… Expand
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Highly Cited
2000
Highly Cited
2000
IRS-2 pathways integrate female reproduction and energy homeostasis
Severe dietary restriction, catabolic states and even short-term caloric deprivation impair fertility in mammals. Likewise… Expand
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Highly Cited
1998
Highly Cited
1998
Enhanced expression of the insulin receptor substrate-2 docking protein in human pancreatic cancer.
Insulin receptor substrate-2 (IRS-2) is a multisite docking protein implicated in mitogenic signaling after activation of the… Expand
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Highly Cited
1996
Highly Cited
1996
Interaction of Insulin Receptor Substrate-2 (IRS-2) with the Insulin and Insulin-like Growth Factor I Receptors
Insulin receptor substrate 2 (IRS-2) has recently been shown to be a substrate of the insulin receptor (IR). In this study we… Expand
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