Insulin Receptor Substrate-2 Protein

Known as: Insulin Receptor Substrate 2, Insulin Receptor Substrate 2 Protein, Insulin Receptor Substrate-2 
 
National Institutes of Health

Related topics

Related topics

3 relations
IRS2 gene

Narrower (1)

IRS2 protein, human

Broader (1)

Insulin Receptor Substrate Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Insulin receptor substrate 2 is a negative regulator of memory formation.
Insulin has been shown to impact on learning and memory in both humans and animals, but the downstream signaling mechanisms… (More)
  • table 1
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
2005
2005
Overexpression of insulin receptor substrate-2 in human and murine hepatocellular carcinoma.
De-regulations in insulin and insulin-like growth factor (IGF) pathways may contribute to hepatocellular carcinoma. Although… (More)
Is this relevant?
Highly Cited
2003
Highly Cited
2003
Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes.
The insulin receptor substrate-2 (Irs2) branch of the insulin/IGF signaling system coordinates peripheral insulin action and… (More)
  • figure 1
  • figure 2
  • figure 3
  • table 1
  • figure 4
Is this relevant?
Highly Cited
2002
Highly Cited
2002
The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth.
Diabetes is caused by an absolute (type 1) or relative (type 2) deficiency of insulin-producing beta cells. The mechanisms… (More)
  • figure 1
  • figure 2
  • table 1
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Regulation of breast cancer cell motility by insulin receptor substrate-2 (IRS-2) in metastatic variants of human breast cancer cell lines
Insulin-like growth factors (IGFs) regulate breast cancer cell proliferation, protect cells from apoptosis, and enhance… (More)
  • figure 1
  • figure 3
  • figure 2
  • figure 5
  • figure 4
Is this relevant?
Highly Cited
2000
Highly Cited
2000
IRS-2 pathways integrate female reproduction and energy homeostasis
Severe dietary restriction, catabolic states and even short-term caloric deprivation impair fertility in mammals. Likewise… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
1999
1999
Human insulin receptor substrate-2: gene organization and promoter characterization.
Insulin receptor substrate-2 (IRS-2) belongs to a family of cytoplasmic adaptor proteins, which link insulin, IGF-1, and cytokine… (More)
Is this relevant?
1998
1998
Enhanced expression of the insulin receptor substrate-2 docking protein in human pancreatic cancer.
Insulin receptor substrate-2 (IRS-2) is a multisite docking protein implicated in mitogenic signaling after activation of the… (More)
  • figure 1
  • figure 3
  • figure 2
  • figure 4
Is this relevant?
Highly Cited
1997
Highly Cited
1997
Leptin activates PI-3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways
We have recently shown that leptin mimicks insulin effects on glucose transport and glycogen synthesis through a… (More)
  • figure 2
Is this relevant?
1996
1996
Growth hormone, interferon-gamma, and leukemia inhibitory factor utilize insulin receptor substrate-2 in intracellular signaling.
In this report, we demonstrate that insulin receptor substrate-2 (IRS-2) is tyrosyl-phosphorylated following stimulation of 3T3… (More)
Is this relevant?