• Publications
  • Influence
Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin.
TLDR
Ghrelin is considered a gastrointestinal peptide contributing to the regulation of diverse functions of the gut-brain axis and there is indeed a possibility that ghrelin analogs, acting as either agonists or antagonists, might have clinical impact. Expand
Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT
TLDR
These findings provide the first evidence that, independent of its acylation, ghrelin gene product may act as a survival factor directly on the cardiovascular system through binding to a novel, yet to be identified receptor, which is distinct from GHSR-1a. Expand
Hypothalamopituitary dysfunction following traumatic brain injury and aneurysmal subarachnoid hemorrhage: a systematic review.
TLDR
Hypopituitarism is a common complication of both traumatic brain injury and aneurysmal subarachnoid hemorrhage and might contribute to morbidity and poor recovery after brain injury. Expand
A consensus on criteria for cure of acromegaly.
TLDR
Criteria to define active acromegaly and disease control were agreed, and several significant changes were made to the 2000 guidelines. Expand
Residual pituitary function after brain injury-induced hypopituitarism: a prospective 12-month study.
TLDR
There is high risk for H in TBI and SAH patients and early diagnosis of PH is always confirmed in the long term, whereas MH and IH were confirmed in 25% only. Expand
Endocrine activities of ghrelin, a natural growth hormone secretagogue (GHS), in humans: comparison and interactions with hexarelin, a nonnatural peptidyl GHS, and GH-releasing hormone.
TLDR
Ghrelin, a natural ligand of GHS-receptor, exerts a strong stimulatory effect on GH secretion in humans, releasing more GH than GHRH and even more than a nonnatural GHS such as HEX, which possesses strong GH-releasing activity but also significantly stimulates PRL, ACTH, and cortisol secretion. Expand
Neuroendocrine and peripheral activities of ghrelin: implications in metabolism and obesity.
TLDR
The theoretical possibility that GHS analogues could become candidate drugs for treatment of pathophysiological conditions in internal medicine totally unrelated to disorders of GH secretion is confronted, particularly, GHS receptor agonists or antagonists acting on appetite could represent new drug intervention in eating disorders. Expand
Expression of ghrelin and of the GH secretagogue receptor by pancreatic islet cells and related endocrine tumors.
TLDR
Findings demonstrate that ghrelin production is not restricted to the stomach but is also present in pancreatic beta-cells and endocrine tumors (regardless of the type of pancreatic hormone produced, if any). Expand
Expression of ghrelin and biological activity of specific receptors for ghrelin and des-acyl ghrelin in human prostate neoplasms and related cell lines.
TLDR
Specific GHS binding sites, other than GHS-R1a and 1b, are present in human prostatic neoplasms. Expand
Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic beta-cells and human islets: involvement of 3',5'-cyclic adenosine monophosphate/protein kinase A,
TLDR
It is demonstrated that AG and UAG promote survival of both beta-cells and human islets and involve cAMP/PKA, ERK1/2, and PI3K/Akt, which are independent of GRLN-R, and are likely mediated by AG/UAG binding sites. Expand
...
1
2
3
4
5
...