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Insulin Receptor Substrate Proteins

Known as: IRS Signaling Adaptor Proteins, Insulin Receptor Substrate Proteins [Chemical/Ingredient] 
A structurally-related group of signaling proteins that are phosphorylated by the INSULIN RECEPTOR PROTEIN-TYROSINE KINASE. The proteins share an N… 
National Institutes of Health

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IRS2 protein, humanIRS4 protein, ratInsulin Receptor Substrate-2 ProteinInsulin Receptor Substrate-3 Protein
In BloodProcess of secretionagonistsantagonists & inhibitors

Papers overview

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2017
2017
[PP.08.29] MARKED INSULIN RESISTANCE IN FAT CELLS OF SUBJECTS WITH INCREASED CARDIOVASCULAR RISK
Objective: Adipose tissue dysfunction may be a pathophysiological factor promoting cardiovascular disease due to altered lipid… 
2014
2014
Insilico docking study of compounds elucidated from helicteres isora fruits with ampkinase- insulin receptor
Insulin receptor (IR) proteins were essential intracellular signaling peptides in the insulin action cascade. Insulin receptor… 
2002
2002
GTK Tyrosine Kinase-induced Alteration of IRS-protein Signalling in Insulin Producing Cells
BackgroundInsulin receptor substrate proteins (IRS) mediate various effects of insulin, including regulation of glucose… 
2002
2002
Interaction of phosphatidylinositolglycan(-peptides) with plasma membrane lipid rafts triggers insulin-mimetic signaling in rat adipocytes.
2001
2001
Selective insulin-induced activation of class IA phosphoinositide 3-kinase in PIKfyve immune complexes from 3T3-L1 adipocytes
2000
2000
The juxtamembrane but not the carboxyl-terminal domain of the insulin receptor mediates insulin's metabolic functions in primary adipocytes and cultured hepatoma cells.
Insulin-stimulated signaling pathways are activated upon interactions between the intracellular domains of the receptor and its… 
1999
1999
Use of an Antisense Strategy to Dissect the Signaling Role of Protein-tyrosine Phosphatase α*
The protein-tyrosine phosphatase PTPα has been proposed to play an important role in controlling the dephosphorylation of a… 
1997
1997
HMG-I(Y) Phosphorylation Status as a Nuclear Target Regulated through Insulin Receptor Substrate-1 and the I4R Motif of the Interleukin-4 Receptor*
Interleukin (IL)-4 is a cytokine that regulates both the growth and differentiation of hematopoietic cells. Its ligand binding… 
1995
1995
Characterization of the Interleukin-4 Nuclear Activated Factor/STAT and Its Activation Independent of the Insulin Receptor Substrate Proteins (*)
The activation of a latent DNA binding factor by interleukin-4 (IL-4), the IL-4 nuclear activated factor (IL-4 NAF), occurs… 
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