IRS2 protein, human

Known as: insulin receptor substrate 2, human, IRS2, IRS-2 protein, human 
Insulin receptor substrate 2 (1338 aa, ~137 kDa) is encoded by the human IRS2 gene. This protein is involved in insulin-dependent signal transduction… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1985-2018
02040608019852018

Papers overview

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Highly Cited
2009
Highly Cited
2009
Hepatic steatosis is present in insulin-resistant obese rodents and is concomitant with active lipogenesis. Hepatic lipogenesis… (More)
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Highly Cited
2007
Highly Cited
2007
Inflammation is associated with obesity and insulin resistance. Proinflammatory cytokines produced by adipose tissue in obesity… (More)
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Highly Cited
2004
Highly Cited
2004
Short term high fat feeding in rats results specifically in hepatic fat accumulation and provides a model of non-alcoholic fatty… (More)
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Highly Cited
2004
Highly Cited
2004
Insulin resistance is a pathophysiological component of type 2 diabetes and obesity and also occurs in states of stress… (More)
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Highly Cited
2003
Highly Cited
2003
Several studies have shown a relationship between interleukin (IL) 6 levels and insulin resistance. We here show that human… (More)
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Highly Cited
2002
Highly Cited
2002
Inflammation associates with peripheral insulin resistance, which dysregulates nutrient homeostasis and leads to diabetes… (More)
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Highly Cited
2000
Highly Cited
2000
In mice with too little fat (lipodystrophy) or too much fat (ob/ob), leptin deficiency leads to hyperglycemia, hyperinsulinemia… (More)
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Highly Cited
2000
Highly Cited
2000
Insulin controls glucose homeostasis by regulating glucose use in peripheral tissues, and its own production and secretion in… (More)
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Highly Cited
1998
Highly Cited
1998
Human type 2 diabetes is characterized by defects in both insulin action and insulin secretion. It has been difficult to identify… (More)
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Highly Cited
1995
Highly Cited
1995
The protein IRS-1 acts as an interface between signalling proteins with Src-homology-2 domains (SH2 proteins) and the receptors… (More)
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