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Genome-wide analysis of mammalian promoter architecture and evolution
These tagging methods allow quantitative analysis of promoter usage in different tissues and show that differentially regulated alternative TSSs are a common feature in protein-coding genes and commonly generate alternative N termini. Expand
Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.
A role for the abnormal regulation of this cytokine in the pathogenesis of obesity-related insulin resistance is suggested as well as the effects of weight reduction by dietary treatment of obesity on the adipose expression of TNF-alpha mRNA. Expand
Dynamics of fat cell turnover in humans
It is shown that adipocyte number is a major determinant for the fat mass in adults, however, the number of fat cells stays constant in adulthood in lean and obese individuals, even after marked weight loss, indicating that thenumber of adipocytes is set during childhood and adolescence. Expand
The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes.
Irbesartan is renoprotective independently of its blood-pressure-lowering effect in patients with type 2 diabetes and microalbuminuria, and serious adverse events were less frequent among the patients treated with the drug. Expand
A promoter-level mammalian expression atlas
It is found that few genes are truly ‘housekeeping’, whereas many mammalian promoters are composite entities composed of several closely separated TSSs, with independent cell-type-specific expression profiles. Expand
Dipeptidyl Peptidase 4 Is a Novel Adipokine Potentially Linking Obesity to the Metabolic Syndrome
DPP4 is a novel adipokine that may impair insulin sensitivity in an autocrine and paracrine fashion and release strongly correlates with adipocyte size, potentially representing an important source of DPP4 in obesity. Expand
Treatment with dietary trans10cis12 conjugated linoleic acid causes isomer-specific insulin resistance in obese men with the metabolic syndrome.
These results reveal important isomer-specific metabolic actions of CLA in abdominally obese humans and provide physiological insights into the role of specific dietary fatty acids as modulators of insulin resistance in humans. Expand
Human beta-2 adrenoceptor gene polymorphisms are highly frequent in obesity and associate with altered adipocyte beta-2 adrenoceptor function.
The findings suggest that genetic variability in the human BAR-2 gene could be of major importance for obesity, energy expenditure, and lipolytic BAR- 2 function in adipose tissue, at least in women. Expand
The adipocyte in insulin resistance: key molecules and the impact of the thiazolidinediones
  • P. Arner
  • Medicine, Biology
  • Trends in Endocrinology & Metabolism
  • 1 April 2003
Factors released from adipose tissue that could contribute to the development of insulin resistance and beta-cell dysfunction are reviewed, including tumour necrosis factor alpha (TNF-alpha), free fatty acids (FFAs), adiponectin, resistin and leptin. Expand
Human fat cell lipolysis: biochemistry, regulation and clinical role.
  • P. Arner
  • Biology, Medicine
  • Best practice & research. Clinical endocrinology…
  • 1 December 2005
The regional variations in lipolysis are further enhanced in obesity and polycystic ovarian syndrome, and are of importance for dyslipidaemia, hyperinsulinaemia and glucose intolerance in these conditions. Expand