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The Hallmarks of Aging
Extending Healthy Life Span—From Yeast to Humans
Dietary restriction and reduced activity of nutrient-sensing pathways may slow aging by similar mechanisms, which have been conserved during evolution, and their potential application to prevention of age-related disease and promotion of healthy aging in humans, and the challenge of possible negative side effects.
Molecular Evolution and Functional Characterization of Drosophila Insulin-Like Peptides
- Sebastian Grönke, D. Clarke, S. Broughton, T. Andrews, L. Partridge
- BiologyPLoS genetics
- 1 February 2010
Loss of brain DILPs blocked the responses of lifespan and fecundity to dietary restriction (DR) and the DR response of these mutants suggests that IIS extends lifespan through mechanisms that both overlap with those of DR and through additional mechanisms that are independent of those at work in DR.
Cost of mating in Drosophila melanogaster females is mediated by male accessory gland products
It is demonstrated here that seminal fluid products from the main cells of the male accessory gland are responsible for the cost of mating in females, and that increasing exposure to these products increases female death rate.
Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands.
- S. Broughton, M. Piper, L. Partridge
- BiologyProceedings of the National Academy of Sciences…
- 22 February 2005
It is shown that ablation of Drosophila insulin-like peptide-producing median neurosecretory cells in the brain leads to increased fasting glucose levels in the hemolymph of adults similar to that found in diabetic mammals and the ablated flies show an extension of median and maximal lifespan and increased resistance to oxidative stress and starvation.
C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins
In vitro and in vivo models to dissect repeat RNA and dipeptide repeat protein toxicity are developed, consistent with a dual toxicity mechanism, whereby both arginine-rich proteins and repeat RNA contribute to C9orf72-mediated neurodegeneration.
Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster
Genome-Wide Transcript Profiles in Aging and Calorically Restricted Drosophila melanogaster
Amino acid imbalance explains extension of lifespan by dietary restriction in Drosophila
Reduced activity of the insulin/insulin-like growth factor signalling pathway extends lifespan in diverse organisms, and it is found that it also protects against the shortening of lifespan with full feeding.
Calories Do Not Explain Extension of Life Span by Dietary Restriction in Drosophila
It is demonstrated that extension of life span by DR in Drosophila is not attributable to the reduction in calorie intake, and reduction of either dietary yeast or sugar can reduce mortality and extend life span, but by an amount that is unrelated to the calorie content of the food.