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The Hallmarks of Aging
Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. This deterioration is the primary risk factor for majorExpand
Extending Healthy Life Span—From Yeast to Humans
Eat Less, Live Long Studies in several model organisms have shown that dietary restriction without malnutrition, or manipulation of nutrient-sensing pathways through mutations or drugs, can increaseExpand
Molecular Evolution and Functional Characterization of Drosophila Insulin-Like Peptides
Multicellular animals match costly activities, such as growth and reproduction, to the environment through nutrient-sensing pathways. The insulin/IGF signaling (IIS) pathway plays key roles inExpand
Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein
The Drosophila melanogaster gene chicoencodes an insulin receptor substrate that functions in an insulin/insulin-like growth factor (IGF) signaling pathway. In the nematode Caenorhabditis elegans,Expand
Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands.
The insulin/insulin-like growth factor-like signaling pathway, present in all multicellular organisms, regulates diverse functions including growth, development, fecundity, metabolic homeostasis, andExpand
C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins
Dipeptide repeat peptides on the attack Certain neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), are associated with expanded dipeptides translated from RNA transcripts ofExpand
Cost of mating in Drosophila melanogaster females is mediated by male accessory gland products
FEMALE Drosophila melanogaster with environmentally1–3 or genetically4 elevated rates of mating die younger than controls. This cost of mating is not attributable to receipt of sperm5. We demonstrateExpand
Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster
Summary The target of rapamycin (TOR) pathway is a major nutrient-sensing pathway that, when genetically downregulated, increases life span in evolutionarily diverse organisms including mammals. TheExpand
Genome-Wide Transcript Profiles in Aging and Calorically Restricted Drosophila melanogaster
BACKGROUND We characterized RNA transcript levels for the whole Drosophila genome during normal aging. We compared age-dependent profiles from animals aged under full-nutrient conditions withExpand