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Ghrelin is a growth-hormone-releasing acylated peptide from stomach
TLDR
The occurrence of ghrelin in both rat and human indicates that GH release from the pituitary may be regulated not only by hypothalamic GHRH, but also by ghrelIn, a peptide specifically releases GH both in vivo and in vitro.
A role for ghrelin in the central regulation of feeding
TLDR
It is shown that ghrelin is involved in the hypothalamic regulation of energy homeostasis and probably has a function in growth regulation by stimulating feeding and release of growth hormone.
Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems.
TLDR
The unique neuronal distribution of orexins and their functional activation of neural circuits suggest specific complex roles of the peptides in autonomic and neuroendocrine control.
Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion.
TLDR
It is demonstrated that nutritional state is a determinant of plasma ghrelin in humans andGhrelin secretion is up-regulated under conditions of negative energy balance and down-regulated in the setting of positive energy balance, suggesting the involvement of gh Relin in the regulation of feeding behavior and energy homeostasis.
The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats.
TLDR
This study indicated that the gastric vagal afferent is the major pathway conveying ghrelin's signals for starvation and GH secretion to the brain.
The role of the vagal nerve in peripheral PYY3-36-induced feeding reduction in rats.
TLDR
It is shown that peripheral PYY(3-36) may transmit satiety signals to the brain in part via the vagal afferent pathway, and bilateral midbrain transections rostral to the nucleus of the solitary tract also abolished PYY-induced reductions in feeding.
Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion.
TLDR
Findings indicate that ghrelin may regulate islet function in an endocrine and/or paracrine manner.
Ghrelin is present in pancreatic α-cells of humans and rats and stimulates insulin secretion
TLDR
Findings indicate that ghrelin may regulate islet function in an endocrine and/or paracrine manner.
Familial transthyretin-type amyloid polyneuropathy in Japan: clinical and genetic heterogeneity.
Familial amyloid polyneuropathy (FAP) was once considered a disease peculiar to endemic areas, but it is now recognized not to be a rare disease among hereditary neuropathic disorders in Japan. FAP
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