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ITPR2 gene

Known as: inositol 1,4,5-trisphosphate receptor type 2, INOSITOL 1,4,5-TRIPHOSPHATE RECEPTOR, TYPE 2, CFAP48 
This gene plays a role in second messenger signaling.
National Institutes of Health

Related topics

Related topics

7 relations
Calcium BindingCalcium SignalingITPR2 protein, humanLigand Binding

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
Reduction of endoplasmic reticulum- mitochondria interactions in beta cells from patients with type 2 diabetes
Type 2 diabetes develops when beta cells are not able to fulfill insulin needs. The role of the endoplasmic reticulum… 
Highly Cited
2014
Highly Cited
2014
Astrocyte IP3R2-dependent Ca2+ signaling is not a major modulator of neuronal pathways governing behavior
Calcium-dependent release of gliotransmitters by astrocytes is reported to play a critical role in synaptic transmission and be… 
Highly Cited
2013
Highly Cited
2013
Cerebral Blood Flow Modulation by Basal Forebrain or Whisker Stimulation Can Occur Independently of Large Cytosolic Ca2+ Signaling in Astrocytes
We report that a brief electrical stimulation of the nucleus basalis of Meynert (NBM), the primary source of cholinergic… 
Highly Cited
2013
Highly Cited
2013
IP3R2 levels dictate the apoptotic sensitivity of diffuse large B-cell lymphoma cells to an IP3R-derived peptide targeting the BH4 domain of Bcl-2
Disrupting inositol 1,4,5-trisphosphate (IP3) receptor (IP3R)/B-cell lymphoma 2 (Bcl-2) complexes using a cell-permeable peptide… 
Review
2007
Review
2007
The IP3 receptor/Ca2+ channel and its cellular function.
The IP3R [IP3 (inositol 1,4,5-trisphosphate) receptor] is responsible for Ca2+ release from the ER (endoplasmic reticulum). We… 
Highly Cited
2007
Highly Cited
2007
Signaling proteins in raft-like microdomains are essential for Ca2+ wave propagation in glial cells.
Highly Cited
2005
Highly Cited
2005
IP3 Receptor Types 2 and 3 Mediate Exocrine Secretion Underlying Energy Metabolism
Type 2 and type 3 inositol 1,4,5-trisphosphate receptors (IP3R2 and IP3R3) are intracellular calcium-release channels whose… 
Highly Cited
2005
Highly Cited
2005
Endothelin-1 – Induced Arrhythmogenic Ca 2 Signaling Is Abolished in Atrial Myocytes of Inositol-1 , 4 , 5-Trisphosphate ( IP 3 ) – Receptor Type 2 – Deficient Mice
Recent studies have suggested that inositol-1,4,5-trisphosphate-receptor (IP3R)–mediated Ca 2 release plays an important role in… 
Highly Cited
2004
Highly Cited
2004
Inositol 1,4,5-trisphosphate receptor subtypes are differentially distributed between smooth muscle and endothelial layers of rat arteries.
Highly Cited
2003
Highly Cited
2003
Hepatitis B virus-related insertional mutagenesis occurs frequently in human liver cancers and recurrently targets human telomerase gene
Integration of Hepatitis B Virus (HBV) DNA into liver cell DNA has been well established, but its implication in liver… 
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