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Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies.
TLDR
Gen expression profiles from 21 breast cancer data sets and identified 587 TNBC cases may be useful in biomarker selection, drug discovery, and clinical trial design that will enable alignment of TNBC patients to appropriate targeted therapies. Expand
Integration of External Signaling Pathways with the Core Transcriptional Network in Embryonic Stem Cells
TLDR
This study uses chromatin immunoprecipitation coupled with ultra-high-throughput DNA sequencing to map the locations of TF-binding sites and identifies important features of the transcriptional regulatory networks that define ES-cell identity. Expand
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells
TLDR
By integrating RNA interference–mediated depletion of Oct4 and Nanog with microarray expression profiling, it is demonstrated that these factors can activate or suppress transcription, and it is shown that common core downstream targets are important to keep ES cells from differentiating. Expand
Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases
TLDR
It is demonstrated that miRNAs are present in the serum and plasma of humans and other animals such as mice, rats, bovine fetuses, calves, and horses, and can serve as potential biomarkers for the detection of various cancers and other diseases. Expand
ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals.
TLDR
It is found that the ER chaperone BiP/GRP78 binds ATF6 and dissociates in response to ER stress and that dissociation of BiP during ER stress allows ATF6 to be transported to the Golgi. Expand
Temporal Collaborative Filtering with Bayesian Probabilistic Tensor Factorization
TLDR
This work proposes a factor-based algorithm that is able to take time into account, and provides a fully Bayesian treatment to avoid tuning parameters and achieve automatic model complexity control. Expand
Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA
TLDR
It is shown that MIR168a could bind to the human/mouse low-density lipoprotein receptor adapter protein 1 (LDLRAP1) mRNA, inhibit LDLRAP1 expression in liver, and consequently decrease LDL removal from mouse plasma, demonstrating that exogenous plant miRNAs in food can regulate the expression of target genes in mammals. Expand
ABAD Directly Links Aß to Mitochondrial Toxicity in Alzheimer's Disease
TLDR
It is demonstrated that Aβ-binding alcohol dehydrogenase (ABAD) is a direct molecular link from Aβ to mitochondrial toxicity and the ABAD-Aβ interaction may be a therapeutic target in Alzheimer's disease. Expand
TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages
TLDR
This work reports that TLR4 and TLR2 specifically activated the endoplasmic reticulum (ER) stress sensor kinase IRE1α and its downstream target, the transcription factor XBP1, identifying an unsuspected critical function for XBP 1 in mammalian host defenses. Expand
RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease
TLDR
Evidence is presented that the 'receptor for advanced glycation end products' (RAGE) is such a receptor, and that it mediates effects of the peptide on neurons and microglia and indicates that it is relevant to the pathogenesis of neuronal dysfunction and death. Expand
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