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Characterization of intracellular signals via tyrosine 1062 in RET activated by glial cell line-derived neurotrophic factor
TLDR
It is suggested that the RAS and PI3-K pathways activated by GDNF bifurcate mainly through SHC bound to tyrosine 1062 in RET, which is important for activation of CREB and NF-κB in GDNF-treated cells, respectively.
A randomised phase III trial comparing gemcitabine with surgery-only in patients with resected pancreatic cancer: Japanese Study Group of Adjuvant Therapy for Pancreatic Cancer
TLDR
It is suggested that adjuvant gemcitabine contributes to prolonged disease-free survival (DFS) in patients undergoing macroscopically curative resection of pancreatic cancer.
Japan Pancreatic Cancer Registry; 30th Year Anniversary: Japan Pancreas Society
TLDR
The improvement of survival of patients with invasive cancer in Japan can be attributed to the introduction of effective chemotherapies, regionalization, and the earlier diagnosis and treatment.
Correlation Between Radiographic Classification and Pathological Grade of Portal Vein Wall Invasion in Pancreatic Head Cancer
TLDR
A retrospective study to clarify the correlation between radiographic type of portal vein (PV) invasion and pathological grade of PV wall invasion, and their correlation with postoperative prognosis found Pancreatectomy with PV resection can be performed safely.
The detection of TP53 mutations in chronic lymphocytic leukemia independently predicts rapid disease progression and is highly correlated with a complex aberrant karyotype
TLDR
In multivariate Cox regression analysis, VH status, TP53 mutation and also isolated TP53 mutations independently predicted rapid disease progression.
Pancreatic Cancer Registry in Japan: 20 Years of Experience
TLDR
Multidisciplinary treatments combined with surgery were performed, and various effects of postoperative chemotherapy after pancreatectomy, intraoperative- and postoperative-radiation therapy, or postoperatively chemotherapy for unresectable tumor, were shown.
Role of adjuvant surgery for patients with initially unresectable pancreatic cancer with a long-term favorable response to non-surgical anti-cancer treatments: results of a project study for
TLDR
Adjuvant surgery for initially unresectable pancreatic cancer patients can be a safe and effective treatment, and the overall survival rate from the initial treatment is extremely high, especially in patients who received non-surgical anti-cancer treatment for more than 240 days.
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