Increased InsP3Rs in the junctional sarcoplasmic reticulum augment Ca2+ transients and arrhythmias associated with cardiac hypertrophy
- D. Harzheim, Mehregan Movassagh, H. Roderick
- BiologyProceedings of the National Academy of Sciences
- 7 July 2009
The data establish that increased InsP3R expression is a general mechanism that underlies remodeling of Ca2+ signaling during heart disease, and in particular, in triggering ventricular arrhythmia during hypertrophy.
Inhibition of Nuclear Import of Calcineurin Prevents Myocardial Hypertrophy
It is concluded that calcineurin is not only capable of dephosphorylating NF-AT, thus enabling its nuclear import, but the presence of calcineURin in the nucleus is also important for fullNF-AT transcriptional activity.
Endothelin-1-stimulated InsP3-induced Ca2+ release is a nexus for hypertrophic signaling in cardiac myocytes.
Protective effects of sphingosine-1-phosphate receptor agonist treatment after myocardial ischaemia-reperfusion.
Pharmacological S1P receptor agonists have distinct effects on ischaemia-reperfusion injury and their efficacy when applied during reperfusion makes them potential candidates for pharmaceutical postconditioning therapy after cardiac ischaemic.
Conditional neuronal nitric oxide synthase overexpression impairs myocardial contractility.
Measuring RF‐induced currents inside implants: Impact of device configuration on MRI safety of cardiac pacemaker leads
The results show that a considerable number of implanted devices may incidentally not develop severe heating in MRI because of their specific configuration in the body, which indicates that hazardous situations might appear during MRI.
Targeted Proteolysis Sustains Calcineurin Activation
- N. Burkard, Jan Becher, Cornelia Heindl, L. Neyses, K. Schuh, O. Ritter
- Biology, MedicineCirculation
- 1 March 2005
It is demonstrated that targeted proteolysis of the CnA autoinhibitory domain under pathological myocardial workload leads to increasedCnA activity in human myocardium and results in nuclear translocation of Cn a in patients with diseasedMyocardium.
Epidemiology of Chagas disease in Europe: many calculations, little knowledge
- Jörn Strasen, T. Williams, G. Ertl, T. Zoller, A. Stich, O. Ritter
- MedicineClinical Research in Cardiology
An overview on the currently available data and calls for a German Chagas surveillance are given and there is a large variation in the estimated numbers on the incidence of ChagAs.
Conditional Overexpression of Neuronal Nitric Oxide Synthase Is Cardioprotective in Ischemia/Reperfusion
It is proposed that conditional transgenic overexpression of nNOS resulted in myocardial protection after ischemia/reperfusion injury because of inhibition of mitochondrial function and a reduction in reactive oxygen species generation.