Xifeng Wu

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Common 5p15.33 and 6p21.33 variants influence lung cancer risk

Yufei Wang, Peter Broderick, +11 authors Richard S. Houlston
Nature Genetics
2008

We conducted a genome-wide association (GWA) study of lung cancer comparing 511,919 SNP genotypes in 1,952 cases and 1,438 controls. The most significant association was attained at 15q25.1… (More)

Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1

Christopher I. Amos, Xifeng Wu, +17 authors Richard S. Houlston
Nature Genetics
2008

To identify risk variants for lung cancer, we conducted a multistage genome-wide association study. In the discovery phase, we analyzed 315,450 tagging SNPs in 1,154 current and former (ever) smoking… (More)

Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer

Xifeng Wu, Yuanqing Ye, +45 authors Jian Gu
Nature Genetics
2009

We conducted a genome-wide association study on 969 bladder cancer cases and 957 controls from Texas. For fast-track validation, we evaluated 60 SNPs in three additional US populations and validated… (More)

Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing

Jianguo Zhang, Junya Fujimoto, +24 authors P. Andrew Futreal
Science
2014

Cancers are composed of populations of cells with distinct molecular and phenotypic features, a phenomenon termed intratumor heterogeneity (ITH). ITH in lung cancers has not been well studied. We… (More)

Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk.

Yuanqing Ye, Kenneth K. Wang, +4 authors Xifeng Wu
Cancer prevention research
2008

MicroRNAs (miRNA) can act as oncogenes or tumor suppressors and modulate the expression of approximately one third of all human genes. To test the hypothesis that adverse alleles in miRNA-related… (More)

Specific HIV integration sites are linked to clonal expansion and persistence of infected cells

Frank M Maldarelli, Xifeng Wu, +9 authors Stephen H. Hughes
Science
2014

The persistence of HIV-infected cells in individuals on suppressive combination antiretroviral therapy (cART) presents a major barrier for curing HIV infections. HIV integrates its DNA into many… (More)

Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma.

Yohei Horikawa, Christopher G Wood, +6 authors Xifeng Wu
Clinical cancer research : an official journal of…
2008

PURPOSE MicroRNAs (miRNA) are a class of small noncoding RNA molecules that have been implicated in a wide variety of basic cellular functions through posttranscriptional regulations on their target… (More)

Energy balance, the PI3K-AKT-mTOR pathway genes, and the risk of bladder cancer.

Jie Lin, Jianming Wang, +5 authors Xifeng Wu
Cancer prevention research
2010

We evaluated the association between energy balance and risk of bladder cancer and assessed the joint effects of genetic variants in the mammalian target of rapamycin (mTOR) pathway genes with energy… (More)

Polymorphisms of folate metabolic genes and susceptibility to bladder cancer: a case-control study.

Jie Lin, Margaret R. Spitz, +6 authors Xifeng Wu
Carcinogenesis
2004

Epidemiological studies have shown an association between low folate intake and an increased cancer risk. Major genes involved in folate metabolism include methylene-tetrahydrofolate reductase… (More)

Glutathione peroxidase 1 gene polymorphism and risk of recurrence in patients with superficial bladder cancer.

Hua Zhao, Dong Liang, Herbert Barton Grossman, Xifeng Wu
Urology
2005

OBJECTIVES To investigate the potential of genetic polymorphism (Pro198Leu) in the human glutathione peroxidase 1 (hGPX1) gene as a biologic marker predictive of bladder cancer recurrence. Given the… (More)

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