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Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1
TLDR
Two SNPs, rs1051730 and rs8034191, mapping to a region of strong linkage disequilibrium within 15q25.1 containing PSMA4 and the nicotinic acetylcholine receptor subunit genes CHRNA3 and CHRNA5, were significantly associated with risk in both replication sets.
Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers.
TLDR
Although genomic alterations are dominated by loss of tumor suppressor genes, 80% of patients harbored at least one genomic alteration in a targetable gene, suggesting that novel approaches to treatment may be possible for this debilitating subset of head and neck cancers.
Common 5p15.33 and 6p21.33 variants influence lung cancer risk
TLDR
A genome-wide association study of lung cancer comparing 511,919 SNP genotypes in 1,952 cases and 1,438 controls confirmed the most significant association was attained at 15q25.1 and identified two newly associated risk loci mapping to 6p21.33 and 5p15.33.
Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing
TLDR
WES data indicate that a larger subclonal mutation fraction may be associated with increased likelihood of postsurgical relapse in patients with localized lung adenocarcinomas, and different mutations are present in different regions of any given lung cancer, and their pattern may predict patient relapse.
Telomere dysfunction: a potential cancer predisposition factor.
TLDR
Telomere length was statistically significantly and inversely associated with baseline and mutagen-induced genetic instability and appears to be associated with increased risks for human bladder, head and neck, lung, and renal cell cancers.
A risk model for prediction of lung cancer.
TLDR
If confirmed in other studies, this risk assessment procedure could use easily obtained clinical information to identify individuals who may benefit from increased screening surveillance for lung cancer.
p53 Genotypes and Haplotypes Associated With Lung Cancer Susceptibility and Ethnicity.
TLDR
Genotype and haplotype frequency distributions were strongly dependent on ethnicity; variant allele frequencies were highest in African-Americans (29.1%) and lowest in Mexican-American (12.2%).
Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer
TLDR
A missense variant (rs2294008) in the PSCA gene showed consistent association with bladder cancer in US and European populations and was identified as a new bladder cancer susceptibility locus.
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