IMP Dehydrogenase

Known as: Dehydrogenase, IMP, Dehydrogenase, Inosine-5-Monophosphate, Inosinic Acid Dehydrogenase 
An enzyme that catalyzes the dehydrogenation of inosine 5'-phosphate to xanthosine 5'-phosphate in the presence of NAD. EC 1.1.1.205.

Topic mentions per year

Topic mentions per year

1961-2017
0102019612017

Papers overview

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2007
2007
We screened the inhibitor of mouse inosine 5'-monophosphate dehydrogenase (IMPDH) type II from natural compounds, and found that… (More)
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Highly Cited
2005
Highly Cited
2005
It is not yet clear to what extent depletion of intracellular GTP pools contributes to the antiviral activity of ribavirin… (More)
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2004
2004
Mutations in several genes encoding components of the RNA polymerase II elongation machinery render S. cerevisiae cells sensitive… (More)
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2000
2000
The enzyme IMP dehydrogenase (IMPDH) catalyzes an essential step in the de novo biosynthesis of guanine nucleotides, namely, the… (More)
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1999
1999
IMP dehydrogenase (IMPDH) is an essential enzyme that catalyzes the first step unique to GTP synthesis. To provide a basis for… (More)
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Highly Cited
1997
Highly Cited
1997
An IMP dehydrogenase gene was isolated from Candida albicans on a approximately 2.9-kb XbaI genomic DNA fragment. The putative… (More)
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Highly Cited
1993
Highly Cited
1993
Human IMP dehydrogenase, a target for anticancer and immunosuppressive chemotherapy, exists as two isoforms, types I and II… (More)
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1992
1992
Human IMP dehydrogenase (IMPDH; EC 1.1.1.205) was recently found to consist of two molecular species (types I and II) with high… (More)
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Highly Cited
1990
Highly Cited
1990
IMP dehydrogenase (EC 1.1.1.205), the rate-limiting enzyme of de novo GTP biosynthesis, is a promising target in antileukemic… (More)
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1984
1984
Tiazofurin, a C-nucleoside, was cytotoxic in hepatoma 3924A cells grown in culture with an LC50 = 7.5 microM. In the culture, a… (More)
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