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IMP Dehydrogenase

Known as: Dehydrogenase, IMP, Dehydrogenase, Inosine-5-Monophosphate, Inosinic Acid Dehydrogenase 
An enzyme that catalyzes the dehydrogenation of inosine 5'-phosphate to xanthosine 5'-phosphate in the presence of NAD. EC 1.1.1.205.
National Institutes of Health

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IMD2 protein, S cerevisiaeIMPDH1, human
In BloodProcess of secretionantagonists & inhibitorsaspects of radiation effects

Papers overview

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Highly Cited
2008
Highly Cited
2008
IMPDH activity in thiopurine-treated patients with inflammatory bowel disease - relation to TPMT activity and metabolite concentrations.
AIMS Azathioprine and 6-mercaptopurine are steroid-sparing drugs used in inflammatory bowel disease (IBD). The polymorphic enzyme… 
Highly Cited
2000
Highly Cited
2000
Pharmacodynamic Monitoring of Mycophenolate Mofetil
Abstract The immunosuppressive activity of Mycophenolate Mofetil (MMF) is based on the reversible inhibition of inosine-5… 
Review
1999
Review
1999
Consequences of IMP dehydrogenase inhibition, and its relationship to cancer and apoptosis.
Inosine 5 -monophosphate dehydrogenase (IMPDH) is a rate-limiting enzyme for the synthesis of GTP and dGTP. Two isoforms of IMPDH… 
Highly Cited
1995
Highly Cited
1995
Pharmacodynamic assessment of mycophenolic acid-induced immunosuppression by measuring IMP dehydrogenase activity.
Pharmacodynamic monitoring of the biological effect of immunosuppressive drugs provides an alternative to traditional therapeutic… 
Highly Cited
1988
Highly Cited
1988
Action of the active metabolites of tiazofurin and ribavirin on purified IMP dehydrogenase.
The inhibitory mechanisms of ribavirin 5'-monophosphate (RMP) and thiazole-4-carboxamide adenine dinucleotide (TAD), the active… 
1988
1988
Enzyme-pattern-targeted chemotherapy with tiazofurin and allopurinol in human leukemia.
Highly Cited
1987
Highly Cited
1987
Purification, characterization, and kinetic analysis of inosine 5'-monophosphate dehydrogenase of Tritrichomonas foetus.
1982
1982
Antitumor agents LV: Effects of genkwadaphnin and yuanhuacine on nucleic acid synthesis of P-388 lymphocytic leukemia cells.
The diterpene esters, genkwadaphnin and yuanhuacine, have been shown to possess significant antileukemic activity in the P-388… 
Highly Cited
1977
Highly Cited
1977
Partial purification, properties and regulation of inosine 5'phosphate dehydrogenase in normal and malignant rat tissues.
IMP dehydrogenase (EC 1.2.1.14) was purified 180-fold from rat liver and from the transplantable rat hepatoma 3924A. The enzymes… 
Highly Cited
1976
Highly Cited
1976
Key enzymes of IMP metabolism: transformation and proliferation-linked alterations in gene expression.
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