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Malignant transformation‐linked imbalance: Decreased xanthine oxidase activity in hepatomas
TLDR
Since glutamine PRPP amidotransferase activity was increased but the opposing enzyme, xanthine oxidase, was decreased in all the hepatomas, the reprogramming of gene expression results in an imbalance that favors synthesis against catabolism, which should confer selective advantages to the cancer cells. Expand
Selective up-regulation of type II inosine 5'-monophosphate dehydrogenase messenger RNA expression in human leukemias.
TLDR
Observations suggest that expression of type II IMPDH is stringently linked with immature characteristics of leukemic cells; thus, it should be a selective target for antileukemic chemotherapy. Expand
Two distinct cDNAs for human IMP dehydrogenase.
TLDR
This is the first report suggesting the existence of two distinct types of human IMP dehydrogenase molecular species which may have different sensitivities to the drugs targeted against IMP dehydrogensase. Expand
IMP dehydrogenase, an enzyme linked with proliferation and malignancy
TLDR
Investigation on purine metabolism showed that in the hepatomas there was an increased capacity in the de novo pathway of biosynthesis of inosine 5′-monophosphate (IMP), as reflected in the increased activity of glutamine PRPP amidotransferase and a decrease in IMP catabolism. Expand
Metabolism of hepatomas of different growth rates in situ and during ischemia.
TLDR
There are a number of biochemical parameters, including initial lactate level, ability to maintain ATP, and the state of the cytoplasmic and mitochondrial oxidation-reduction couples, that exhibit a correlation with tumor growth rate. Expand
The molecular correlation concept of neoplasia.
TLDR
The metabolic pattern identified in the spectrum of liver tumors of different growth rates offers a framework for experimental testing and application of these concepts to other types of tumors and to chemotherapy. Expand
Partial purification, properties and regulation of inosine 5'phosphate dehydrogenase in normal and malignant rat tissues.
TLDR
It is concluded that IMP dehydrogenase is a key enzyme in the regulation of GTP production, and thus involved in regulation of nucleic acid biosynthesis, and in livers of starved rats where all enzymes, except those involved in gluconeogenesis, showed decreased activity IMP dehydrogensase activity was increased; this change was accompanied by a rise in hepatic GTP concentrations. Expand
Increased CTP synthetase activity in cancer cells
TLDR
CTP synthetase activity increased in all the hepatomas examined, the activity being highest in the rapidly growing tumours, indicating that in liver neoplasia the activity of this enzyme is both transformation- and progression-linked. Expand
Proliferation-linked regulation of type II IMP dehydrogenase gene in human normal lymphocytes and HL-60 leukemic cells.
TLDR
The low level of type II IMPDH mRNA in normal lymphocytes was up-regulated by phytohemagglutinin stimulation, and the type II mRNA expression in quiescent HL-60 cells was also elevated 2.8-fold by serum stimulation. Expand
Regulation of GTP biosynthesis.
TLDR
In support of enzyme-pattern-targeted chemotherapy, evidence was provided for synergistic chemotherapy with tiazofurin (inhibitor of IMPDH) and hypoxanthine (competitive inhibitor of GPRT and guanine salvage activity) in patients and in tissue culture cell lines. Expand
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