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IMP dehydrogenase, an enzyme linked with proliferation and malignancy
Investigation on purine metabolism showed that in the hepatomas there was an increased capacity in the de novo pathway of biosynthesis of inosine 5′-monophosphate (IMP), as reflected in the increased activity of glutamine PRPP amidotransferase and a decrease in IMP catabolism.
Energy metabolism of tumor cells. Requirement for a form of hexokinase with a propensity for mitochondrial binding.
Increased CTP synthetase activity in cancer cells
CTP synthetase activity increased in all the hepatomas examined, the activity being highest in the rapidly growing tumours, indicating that in liver neoplasia the activity of this enzyme is both transformation- and progression-linked.
Metabolism of hepatomas of different growth rates in situ and during ischemia.
There are a number of biochemical parameters, including initial lactate level, ability to maintain ATP, and the state of the cytoplasmic and mitochondrial oxidation-reduction couples, that exhibit a correlation with tumor growth rate.
Partial purification, properties and regulation of inosine 5'phosphate dehydrogenase in normal and malignant rat tissues.
It is concluded that IMP dehydrogenase is a key enzyme in the regulation of GTP production, and thus involved in regulation of nucleic acid biosynthesis, and in livers of starved rats where all enzymes, except those involved in gluconeogenesis, showed decreased activity IMP dehydrogensase activity was increased; this change was accompanied by a rise in hepatic GTP concentrations.
Isozyme patterns of glycogen phosphorylase in rat tissues and transplantable hepatomas.
The Morris and Yoshida hepatomas are considered to be a prototype whose appearance in hepatomas is one of many known examples of fetal protein expression in cancer.
Studies on the development, biochemistry, and biology of experimental hepatomas.
- H. Morris
- BiologyAdvances in cancer research
Mitochondrial malic enzymes. Mitochondrial NAD(P)+-dependent malic enzyme activity and malate-dependent pyruvate formation are progression-linked in Morris hepatomas.
- L. Sauer, R. Dauchy, W. Nagel, H. Morris
- Biology, Computer ScienceThe Journal of biological chemistry
- 10 May 1980
Examination of mitochondria from liver and from six transplantable hepatomas of different growth rates for NAD(P)+-dependent malic enzyme and for malate-de-pendent pyruvate formation found no evidence of intramitochondrial pyruVate formation.
Ribonucleotide reductase and cell proliferation. I. Variations of ribonucleotide reductase activity with tumor growth rate in a series of rat hepatomas.
- H. Elford, M. Freese, E. Passamani, H. Morris
- Biology, ChemistryThe Journal of biological chemistry
- 25 October 1970
Data indicate that the ribonucleotide reductase reaction is a rate-limiting step in DNA synthesis and cell division and that enzyme synthesis and degradation may be involved in control of this reaction.
Superoxide dismutase and superoxide radical in Morris hepatomas.
Results are consistent with the hypothesis that total SOD and Mn SOD specific activity is decreased in all tumor homogenates and in isolated mitochondria from normal rat liver and three Morris hepatomas, indicating that mitochondrial SOD is almost entirely manganese containing.