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Malignant transformation‐linked imbalance: Decreased xanthine oxidase activity in hepatomas
Since glutamine PRPP amidotransferase activity was increased but the opposing enzyme, xanthine oxidase, was decreased in all the hepatomas, the reprogramming of gene expression results in an imbalance that favors synthesis against catabolism, which should confer selective advantages to the cancer cells. Expand
Molecular mechanisms in the antiproliferative action of quercetin.
Early down-regulation of the c-myc and Ki-ras oncogenes and rapid reduction of inositol-1,4,5-trisphosphate (IP3) concentration are part of the antiproliferative action of quercetin and appear to relate to induction of differentiation and/or apoptotic program of K562 leukemia cells treated with quercETin. Expand
Imbalance of purine metabolism in hepatomas of different growth rates as expressed in behavior of xanthine oxidase (EC 22.214.171.124).
Since xanthine oxidase activity was decreased in all examined hepatomas, including the slowest-growing, well-differentiated neoplasms, the altered activity of this enzyme appears to be an imbalance that favors the synthetic over the catabolic potential, which should confer selective advantages to the cancer cells. Expand
Targeted and non-targeted actions of anti-cancer drugs.
These results are a strong argument for discovering and utilizing inhibitors of purine and pyrimidine salvage enzymes to achieve more successful enzyme-pattern-targeted chemotherapy and to avoid development of resistant clones of cancer cells. Expand
Enzymic capacities of purine de Novo and salvage pathways for nucleotide synthesis in normal and neoplastic tissues.
The enzymic capacities of the de novo and the salvage pathways for purine nucleotide synthesis were compared in rat in normal, differentiating, and regenerating liver, and in three hepatomas of widely different growth rates, showing high activities and the high affinity to PRPP of the purine phosphoribosyltransferases might explain the lack of linkage of the behavior of these enzymal activities with proliferation in normal or differentiating tissues. Expand
Biochemical programs of slowly and rapidly growing human colon carcinoma xenografts.
The results indicate the applicability of the molecular correlation concept to human colon neoplasia and should be helpful in the rational design of enzyme pattern-targeted chemotherapy of colon tumors. Expand
Multi-enzyme-targeted chemotherapy by acivicin and actinomycin.
Results are consistent with an interpretation that acivicin acts either as a tight-binding inhibitor or as an inactivator through alkylation of the enzymes of glutamine utilization, and the synergistic biological results of combination chemotherapy with ac civicin and actinomycin can be accounted for. Expand
Linkage of reduction in 1-phosphatidylinositol 4-kinase activity and inositol 1,4,5-trisphosphate concentration in human ovarian carcinoma cells treated with quercetin.
- N. Prajda, R. L. Singhal, Y. Yeh, E. Oláh, K. Look, G. Weber
- Biology, Medicine
- Life sciences
- 31 March 1995
Inhibition by quercetin of the enhanced capacity for operation of signal transduction in human ovarian carcinoma cells is demonstrated for the first time, thus providing a novel target in cancer cells. Expand
Regulation of the signal transduction program by drugs.
Key aspects of the behavior of signal transduction activity in normal and cancer cells are clarified and tiazofurin, quercetin and genistein, which attack different targets and different phases of the cell cycle, proved to be synergistic in OVCAR-5 cells. Expand
Regulation of signal transduction.
- G. Weber, R. L. Singhal, N. Prajda, Y. Yeh, K. Look, G. Sledge
- Biology, Medicine
- Advances in enzyme regulation
Linkage with malignant proliferation was indicated by the observation that in rat hepatomas the enzyme activities increased 5- to 9-fold and were highest in rapidly growing hepatoma 3924A and in human primary ovarian carcinoma PI and PIP kinase activities were elevated 4.4 and 2.9-fold, respectively. Expand