IKZF1 gene

Known as: IKZF1, IKAROS family zinc finger 1, ZNFN1A1 
This gene is involved in B-cell and T-cell maturation.
National Institutes of Health

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5 relations
DNA-Binding Protein IkarosHomo sapiensTranscriptional Regulationdna binding

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IKZF1 wt Allele

Papers overview

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Highly Cited
2014
Highly Cited
2014
Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells
Lenalidomide is a drug with clinical efficacy in multiple myeloma and other B cell neoplasms, but its mechanism of action is… (More)
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Highly Cited
2011
Highly Cited
2011
Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is a complex trait characterised by the production of a range of auto-antibodies and a diverse… (More)
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Review
2010
Review
2010
Novel mutations and their functional and clinical relevance in myeloproliferative neoplasms: JAK2, MPL, TET2, ASXL1, CBL, IDH and IKZF1
Myeloproliferative neoplasms (MPNs) originate from genetically transformed hematopoietic stem cells that retain the capacity for… (More)
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Highly Cited
2010
Highly Cited
2010
Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia.
Gene expression profiling of 207 uniformly treated children with high-risk B-progenitor acute lymphoblastic leukemia revealed 29… (More)
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Highly Cited
2010
Highly Cited
2010
IKZF1 deletions predict relapse in uniformly treated pediatric precursor B-ALL
Relapse is the most common cause of treatment failure in pediatric acute lymphoblastic leukemia (ALL) and is often difficult to… (More)
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Highly Cited
2007
Highly Cited
2007
Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia
Chromosomal aberrations are a hallmark of acute lymphoblastic leukaemia (ALL) but alone fail to induce leukaemia. To identify… (More)
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Highly Cited
2005
Highly Cited
2005
The G protein-gated potassium current I(K,ACh) is constitutively active in patients with chronic atrial fibrillation.
BACKGROUND The molecular mechanism of increased background inward rectifier current (IK1) in atrial fibrillation (AF) is not… (More)
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Highly Cited
2003
Highly Cited
2003
Thymopoiesis independent of common lymphoid progenitors
Early T lineage progenitors (ETPs) in the thymus are thought to develop from common lymphoid progenitors (CLPs) in the bone… (More)
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Highly Cited
1993
Highly Cited
1993
Ionic bases for electrophysiological distinctions among epicardial, midmyocardial, and endocardial myocytes from the free wall of the canine left ventricle.
Recent studies from our laboratory involving syncytial preparations have delineated electrophysiological distinctions between… (More)
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Highly Cited
1988
Highly Cited
1988
Comparison of potassium currents in rabbit atrial and ventricular cells.
1. In rabbit and human hearts there are significant differences in the action potential configuration in atrium and ventricle… (More)
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