DNA-Binding Protein Ikaros

Known as: Lymphoid Transcription Factor LyF-1, ZNFN1A1, IKAROS Family Zinc Finger 1 Protein 1 
DNA-binding protein Ikaros (519 aa, ~58 kDa) is encoded by the human IKZF1 gene. This protein is a transcriptional enhancer that is involved in B… (More)
National Institutes of Health

Papers overview

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2014
2014
Cereblon (CRBN) mediates immunomodulatory drug (IMiD) action in multiple myeloma (MM). Using 2 different methodologies, we… (More)
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Highly Cited
2014
Highly Cited
2014
Lenalidomide is a drug with clinical efficacy in multiple myeloma and other B cell neoplasms, but its mechanism of action is… (More)
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Highly Cited
2010
Highly Cited
2010
To resolve the genetic heterogeneity within pediatric high-risk B-precursor acute lymphoblastic leukemia (ALL), a clinically… (More)
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Highly Cited
2010
Highly Cited
2010
Expression profiling has shown 2 main and clinically distinct subtypes of diffuse large B-cell lymphomas (DLBCLs): germinal… (More)
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Highly Cited
2010
Highly Cited
2010
Response to therapy as determined by minimal residual disease (MRD) is currently used for stratification in treatment protocols… (More)
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Highly Cited
2009
Highly Cited
2009
PURPOSE The causes of the aggressive nature of BCR-ABL1-positive adult acute lymphoblastic leukemia (ALL) are unknown. To… (More)
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Highly Cited
2008
Highly Cited
2008
The Philadelphia chromosome, a chromosomal abnormality that encodes BCR–ABL1, is the defining lesion of chronic myelogenous… (More)
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Highly Cited
2008
Highly Cited
2008
Ikaros plays an important role in the control of differentiation and proliferation of all lymphoid lineages. The expression of… (More)
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Highly Cited
2007
Highly Cited
2007
Chromosomal aberrations are a hallmark of acute lymphoblastic leukaemia (ALL) but alone fail to induce leukaemia. To identify… (More)
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