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The RNA polymerase II core promoter.
Although core promoter structure was originally thought to be invariant, a remarkable degree of diversity has become apparent and this article reviews the structural and functional diversity of the RNA polymerase II core promoter. Expand
Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors.
It is shown that microbial lipoproteins are potent stimulators of IL-12 production by human macrophages, and that induction is mediated by Toll-like receptors (TLRs), and that Activation of TLRs by microbes may initiate innate defense mechanisms against infectious pathogens. Expand
The “initiator” as a transcription control element
The Inr constitutes the simplest functional promoter that has been identified and provides one explanation for how promoters that lack TATA elements direct transcription initiation. Expand
A role for Dicer in immune regulation
It is shown that regulatory T (T reg) cells have a miRNA profile distinct from conventional CD4 T cells, and results suggest that T reg cell development involves Dicer-generated RNAs. Expand
A Unifying Model for the Selective Regulation of Inducible Transcription by CpG Islands and Nucleosome Remodeling
A broad mechanistic framework for the transcriptional induction of mammalian primary response genes by Toll-like receptors and other stimuli is described, which includes CpG-island promoters, which facilitate promiscuous induction from constitutively active chromatin without a requirement for SWI/SNF nucleosome remodeling complexes. Expand
Association of Transcriptionally Silent Genes with Ikaros Complexes at Centromeric Heterochromatin
It is shown that transcriptionally inactive but not transcriptionally active genes associate with Ikaros-heterochromatin foci, which support a model of organization of the nucleus in which repressed genes are selectively recruited into centromeric domains. Expand
Transcriptional Regulation in Eukaryotes: Concepts, Strategies and Techniques
Preface Overview Abbreviations and Acronyms 1. A Primer on Transcriptional Regulation in Mammalian Cells 2. Initial Strategic Issues 3. Transcription Initiation Site Mapping 4. Functional Assays forExpand
DNA sequence requirements for transcriptional initiator activity in mammalian cells.
Almost every functional Inr that has been described fits into the consensus sequence that is defined, and the simplest model to explain these results is that all or most Inrs are recognized by a universal binding protein, similar to the functional recognition of all TATA sequences by the same TATA-binding protein. Expand
T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer
In developing thymocytes, Dicer was not required for the maintenance of transcriptional silencing at pericentromeric satellite sequences, so it may have limited impact on the implementation of some lineage-specific gene expression programs. Expand
Transcript Dynamics of Proinflammatory Genes Revealed by Sequence Analysis of Subcellular RNA Fractions
The results provide a high-resolution view of the relationship between defined promoter and chromatin properties and the temporal regulation of diverse classes of coexpressed genes and a striking accumulation of full-length yet incompletely spliced transcripts in the chromatin fraction. Expand