• Publications
  • Influence
Recruitment of functional GABAA receptors to postsynaptic domains by insulin
  • Q. Wan, Z. Xiong, +6 authors Y. T. Wang
  • Biology, Medicine
  • Nature
  • 14 August 1997
Modification of synaptic strength in the mammalian central nervous system (CNS) occurs at both pre- and postsynaptic sites,. However, because postsynaptic receptors are likely to be saturated byExpand
L-type Ca2+ channels provide a major pathway for iron entry into cardiomyocytes in iron-overload cardiomyopathy
TLDR
The results indicate that cardiac LVDCCs are key transporters of iron into cardiomyocytes under iron-overloaded conditions, and potentially represent a new therapeutic target to reduce the cardiovascular burden from iron overload. Expand
Myelin in multiple sclerosis is developmentally immature.
TLDR
It is determined that myelin obtained from victims of MS is arrested at the level of the first growth spurt and is therefore developmentally immature and is more susceptible to degradation by one or a combination of factors providing the initial antigenic material to the immune system. Expand
Mutations in NHLRC1 cause progressive myoclonus epilepsy
TLDR
A second gene associated with Lafora progressive myoclonus epilepsy is identified, NHLRC1 (also called EPM2B), which encodes malin, a putative E3 ubiquitin ligase with a RING finger domain and six NHL motifs, suggesting they operate in a related pathway protecting against polyglucosan accumulation and epilepsy. Expand
Targeted inactivation of sister of P-glycoprotein gene (spgp) in mice results in nonprogressive but persistent intrahepatic cholestasis.
  • R. Wang, M. Salem, +7 authors V. Ling
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 13 February 2001
TLDR
The knockout of spgp gene in mice results in intrahepatic cholestasis, but with significantly less severity than PFIC2 in humans, and mutant mice display a significant increase in the secretion of cholesterol and phospholipids into the bile. Expand
The Chloride Channel ClC-4 Contributes to Endosomal Acidification and Trafficking*
TLDR
Confocal micrographs of proximal tubules and cultured epithelial cells revealed that the related protein ClC-4 is expressed in endosomal membranes suggesting that this channel may also contribute to the function of this organelle, and prompts future investigation of the role of Cl C-4 in renal function in health and in Dent's disease. Expand
Laforin preferentially binds the neurotoxic starch-like polyglucosans, which form in its absence in progressive myoclonus epilepsy.
TLDR
Using immunogold electron microscopy, it is shown that laforin is found in close proximity to the ER surrounding the polyglucosan accumulations, and establishes for the first time a direct association between the disease-defining storage product and disease protein. Expand
Mutation I810N in the α3 isoform of Na+,K+-ATPase causes impairments in the sodium pump and hyperexcitability in the CNS
TLDR
The functional significance of the Na+,K+-ATPase α3 isoform in the control of epileptiform activity and seizure behavior is revealed and it is revealed that the epilepsy in Myk/+ mice and in vitro hyperexcitability could be prevented by delivery of additional copies of wild-type Na+K+. Expand
Myelin localization of peptidylarginine deiminases 2 and 4: comparison of PAD2 and PAD4 activities
TLDR
In myelin isolated from patients with MS, the amounts of both PAD2 and PAD4 enzymes were increased compared with that in normals, and the citrullinated proteins were also increased, supporting the view that an increase in citruLLinated proteins resulting from increased PAD 2 and 4 is an important change in the pathogenesis of MS. Expand
Expression of the cystic fibrosis gene in non-epithelial invertebrate cells produces a regulated anion conductance
TLDR
It is demonstrated that CFTR can function in heterologous nonepithelial cells and lend support to the possibility thatCFTR may itself be a regulated anion channel. Expand
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