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Pathogenetic mechanisms in thyroid follicular-cell neoplasia
TLDR
Defects in transcriptional and post-transcriptional regulation of adhesion molecules and cell-cycle control elements seem to affect tumour progression, and this information can provide powerful ancillary diagnostic tools and can also be used to identify new therapeutic targets. Expand
The prevalence of pituitary adenomas
TLDR
The goals of the current study were to determine the prevalence of pituitary adenomas and to explore the clinical relevance of the findings. Expand
The pathogenesis of pituitary tumours
TLDR
Pituitary tumours are common and show a range of hormonal and proliferative behaviours that provide a model for the study of neoplasia mechanisms, although there are many differences in disease pathogenesis between mice and humans. Expand
Immunohistochemical Diagnosis of Papillary Thyroid Carcinoma
TLDR
This panel of three immunohistochemical markers provides a useful means of diagnosing papillary carcinoma and provides an objective and reproducible tool for the analysis of difficult thyroid nodules. Expand
The spectrum and significance of primary hypophysitis.
TLDR
It is concluded that the optimal management of patients with hyophysitis requires a high index of suspicion before extensive surgical resection, and conservative, supportive treatment with or without surgical decompression is generally favored over aggressive and extensive surgery resection that results in hypopituitarism. Expand
Clinical case seminar: lymphocytic hypophysitis: clinicopathological findings.
TLDR
It is concluded that lymphocytic hypophysitis should be considered in the differential diagnosis of females with pituitary enlargement presenting in the peripartum period as well as those patients in whompituitary hormone deficiency and/or excess is noted in association with a co-existing autoimmune disorder. Expand
Diagnosis and management of hyperprolactinemia.
TLDR
The diagnostic approach and management of hyperprolactinemia in various clinical settings are described, with emphasis on newer diagnostic strategies and the role of various therapeutic options, including treatment with selective dopamine agonists. Expand
The cytogenesis and pathogenesis of pituitary adenomas.
TLDR
A model of adenohypophysial cytodifferentiation for pituitary Adenoma development and progression and an integrated approach to multistep tumorigenesis are presented. Expand
Distinct multiple RET/PTC gene rearrangements in multifocal papillary thyroid neoplasia.
TLDR
The results indicate that RET/PTC oncogene rearrangements may play a role in early-stage papillary thyroid carcinogenesis, but they seem to be less important in determining progression to clinically-evident disease. Expand
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