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ERK1/2 mediates TNF‐α‐induced matrix metalloproteinase‐9 expression in human vascular smooth muscle cells via the regulation of NF‐κB and AP‐1: Involvement of the ras dependent pathway
The findings herein indicate the activation of the Ras/ERK pathway contributes to the induction of MMP‐9 expression in HASMC. Expand
Novel and therapeutic effect of caffeic acid and caffeic acid phenyl ester on hepatocarcinoma cells: complete regression of hepatoma growth and metastasis by dual mechanism
The results confirm the therapeutic potential of the compounds and suggest that the antimetastatic and anti‐tumor effects of CA and CAPE are mediated through the selective suppression of MMP‐9 enzyme activity and transcriptional down‐regulation by the dual inhibition of NF‐κB as well as M MP‐9 catalytic activity. Expand
Hepatitis B viral HBx induces matrix metalloproteinase‐9 gene expression through activation of ERKs and PI‐3K/AKT pathways: Involvement of invasive potential
It is shown that the HBx protein stimulates the activities of the PI‐3K‐Akt/ protein kinase B (PKB) as well as extracellular signal‐regulated kinase 1/2 (ERK1/2) in HBx‐transfected cells. Expand
Ganglioside GM3 inhibits VEGF/VEGFR-2-mediated angiogenesis: direct interaction of GM3 with VEGFR-2.
It is shown that GM3 regulated the activity of various downstream signaling pathways and biological events through the inhibition of VEGF-stimulated VEGFR-2 activation in vascular endothelial cells in vitro and inhibition of angiogenesis and tumor cell proliferation. Expand
Quercetin exerts multiple inhibitory effects on vascular smooth muscle cells: role of ERK1/2, cell-cycle regulation, and matrix metalloproteinase-9.
Findings indicate the efficacy of quercetin in inhibiting cell proliferation, G1- to S-phase cell-cycle progress, and MMP-9 expression through the transcription factors NF-kappaB and AP-1 on TNF-alpha-induced HASMC. Expand
Resveratrol inhibits inducible nitric oxide synthase and cyclooxygenase-2 expression in beta-amyloid-treated C6 glioma cells.
Results indicate that modulation of nuclear factor-kappaB (NF- kappaB) activity is involved in the neuroprotective action of resveratrol against beta-amyloid-induced toxicity. Expand
PTEN induces G1 cell cycle arrest and inhibits MMP-9 expression via the regulation of NF-kappaB and AP-1 in vascular smooth muscle cells.
PTEN expression has the potent inhibitory effect on DNA synthesis of cultured VSMC in the presence of PDGF and the efficacy of PTEN in inhibiting cell proliferation, G1-S phase cell cycle progress, and MMP-9 expression through the transcription factors NF-kappaB and AP-1 in VSMC is indicated. Expand
The naturally occurring biflavonoid, ochnaflavone, inhibits LPS-induced iNOS expression, which is mediated by ERK1/2 via NF-kappaB regulation, in RAW264.7 cells.
It is reported here, for the first time, that LPS-induced iNOS expression was abolished by OC in RAW264.7 cells through by blocking the inhibition of transcription factor NF-kappaB binding activities. Expand
Chemoprevention of Scutellaria bardata on human cancer cells and tumorigenesis in skin cancer
The data suggest that Scutellaria barbata D. Don merits investigation as a potential cancer chemopreventive agent in humans, especially in gynecological cancers. Expand
SARS-CoV-2 Evolutionary Adaptation toward Host Entry and Recognition of Receptor O-Acetyl Sialylation in Virus–Host Interaction
  • Cheorl-Ho Kim
  • Biology, Medicine
  • International journal of molecular sciences
  • 1 June 2020
The structure and sialobiology of SARS-CoV-2 are discussed in order to encourage and activate public research on glycan-specific interaction-based drug creation in the near future and lead to better understanding of virus evolution toward transitional host tropism. Expand