CREB Phosphorylation and Dephosphorylation: A Ca2+- and Stimulus Duration–Dependent Switch for Hippocampal Gene Expression
Three types of neuronal calcium channel with different calcium agonist sensitivity
Evidence is reported for the coexistence of three types of Ca channel in sensory neurones of the chick dorsal root ganglion and the dihydropyridine Ca agonist Bay K 8644 strongly increases the opening probability of L-, but not T- or N-type channels.
Inhibition of postsynaptic PKC or CaMKII blocks induction but not expression of LTP.
Both postsynaptic PKC and CaMKII are required for the induction of LTP and a presynaptic protein kinase appears to be necessary for the expression of L TP, and both post synapses and protein kinases are sensitive to externally applied H-7.
Electric current flow in excitable cells
Conduction of Electrical Current to and Through the Human February 6th, 2017 PART A BASICS OF ELECTRICITY AND HOW IT INTERACTS WITH THE HUMAN BODY Electric shock is defined as a sudden violent…
Calmodulin supports both inactivation and facilitation of L-type calcium channels
Calmodulin is shown to be a critical Ca2+ sensor for both inactivation and facilitation, and that the nature of the modulatory effect depends on residues within the IQ motif important for calmodulin binding.
Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists
The dihydropyridine Ca agonist Bay K 8644 enhances Ca channel current by promoting mode 2, while the Ca antagonists nitrendipine and nimodipine inhibit the current by favouring mode 0.
Roles of N-type and Q-type Ca2+ channels in supporting hippocampal synaptic transmission.
A role for alpha 1A subunits in synaptic transmission is suggested and the idea that neurotransmitter release may depend on multiple types of calcium channels under physiological conditions is supported.
Adaptation to Synaptic Inactivity in Hippocampal Neurons
Signaling from Synapse to Nucleus: Postsynaptic CREB Phosphorylation during Multiple Forms of Hippocampal Synaptic Plasticity