R. Tsien

Publications316
h-index128
Citations59,772
Highly Influential Citations2,618
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CREB Phosphorylation and Dephosphorylation: A Ca2+- and Stimulus Duration–Dependent Switch for Hippocampal Gene Expression
TLDR
Two important Ca2+/calmodulin (CaM)-regulated mechanisms in hippocampal neurons are found: a CaM kinase cascade involving nuclear CaMKIV and a calcineurin-dependent regulation of nuclear protein phosphatase 1 activity. Expand
Pharmacological dissection of multiple types of Ca2+ channel currents in rat cerebellar granule neurons
  • A. Randall, R. Tsien
  • Chemistry, Medicine
  • The Journal of neuroscience : the official…
  • 1 April 1995
TLDR
The Q-type current, the largest of the current components in the granule neurons, resembles currents that can be generated in Xenopus oocytes by expression of cloned alpha 1A subunits. Expand
Inhibition of postsynaptic PKC or CaMKII blocks induction but not expression of LTP.
TLDR
Both postsynaptic PKC and CaMKII are required for the induction of LTP and a presynaptic protein kinase appears to be necessary for the expression of L TP, and both post synapses and protein kinases are sensitive to externally applied H-7. Expand
Three types of neuronal calcium channel with different calcium agonist sensitivity
TLDR
Evidence is reported for the coexistence of three types of Ca channel in sensory neurones of the chick dorsal root ganglion and the dihydropyridine Ca agonist Bay K 8644 strongly increases the opening probability of L-, but not T- or N-type channels. Expand
Calmodulin supports both inactivation and facilitation of L-type calcium channels
TLDR
Calmodulin is shown to be a critical Ca2+ sensor for both inactivation and facilitation, and that the nature of the modulatory effect depends on residues within the IQ motif important for calmodulin binding. Expand
Electric current flow in excitable cells
Conduction of Electrical Current to and Through the Human February 6th, 2017 PART A BASICS OF ELECTRICITY AND HOW IT INTERACTS WITH THE HUMAN BODY Electric shock is defined as a sudden violent… Expand
Roles of N-type and Q-type Ca2+ channels in supporting hippocampal synaptic transmission.
TLDR
A role for alpha 1A subunits in synaptic transmission is suggested and the idea that neurotransmitter release may depend on multiple types of calcium channels under physiological conditions is supported. Expand
Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists
TLDR
The dihydropyridine Ca agonist Bay K 8644 enhances Ca channel current by promoting mode 2, while the Ca antagonists nitrendipine and nimodipine inhibit the current by favouring mode 0. Expand
Multiple types of neuronal calcium channels and their selective modulation
TLDR
Efforts at classifying multiple types of Ca 2+ channels according to differences in their gating, ionic conductance and pharmacology are summarized. Expand
Adaptation to Synaptic Inactivity in Hippocampal Neurons
TLDR
These results extend beyond "synaptic homeostasis" to involve more profound changes that can be better described as "metaplasticity", and include a dramatic shift toward synaptic drive contributed by the Ca2+-permeable homomeric GluR1 receptors. Expand
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