R. Tsien

Publications274
h-index122
Citations53,874
Highly Influential Citations2,600
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Kinetic and pharmacological properties distinguishing three types of calcium currents in chick sensory neurones.
1. Calcium currents in cultured dorsal root ganglion (d.r.g.) cells were studied with the whole‐cell patch‐clamp technique. Using experimental conditions that suppressed Na+ and K+ currents, and 3‐10… Expand
  • 1,307
  • 91
CREB Phosphorylation and Dephosphorylation: A Ca2+- and Stimulus Duration–Dependent Switch for Hippocampal Gene Expression
While changes in gene expression are critical for many brain functions, including long-term memory, little is known about the cellular processes that mediate stimulus-transcription coupling at… Expand
  • 1,078
  • 90
  • Open Access
Pharmacological dissection of multiple types of Ca2+ channel currents in rat cerebellar granule neurons
  • A. Randall, R. Tsien
  • Biology, Medicine
  • The Journal of neuroscience : the official…
  • 1 April 1995
The diversity of Ca2+ channel types in rat cerebellar granule neurons was investigated with whole-cell recordings (5 mM external Ba2+). Contributions of five different high-voltage-activated Ca2+… Expand
  • 825
  • 86
  • Open Access
Three types of neuronal calcium channel with different calcium agonist sensitivity
How many types of calcium channels exist in neurones? This question is fundamental to understanding how calcium entry contributes to diverse neuronal functions such as transmitter release, neurite… Expand
  • 2,136
  • 62
Inhibition of postsynaptic PKC or CaMKII blocks induction but not expression of LTP.
Long-term potentiation (LTP) of synaptic transmission is a widely studied cellular example of synaptic plasticity. However, the identity, localization, and interplay among the biochemical signals… Expand
  • 1,270
  • 61
Calmodulin supports both inactivation and facilitation of L-type calcium channels
L-type Ca2+ channels support Ca2+ entry into cells, which triggers cardiac contraction, controls hormone secretion from endocrine cells and initiates transcriptional events that support learning and… Expand
  • 812
  • 56
Roles of N-type and Q-type Ca2+ channels in supporting hippocampal synaptic transmission.
Several types of calcium channels found in the central nervous system are possible participants in triggering neurotransmitter release. Synaptic transmission between hippocampal CA3 and CA1 neurons… Expand
  • 937
  • 52
  • Open Access
Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists
Single cardiac transmembranous Ca channels have three modes of gating behaviour in the absence of drugs, expressed as current records with brief openings (mode 1), with no openings because of channel… Expand
  • 1,212
  • 48
Adaptation to Synaptic Inactivity in Hippocampal Neurons
In response to activity deprivation, CNS neurons undergo slow adaptive modification of unitary synaptic transmission. The changes are comparable in degree to those induced by brief intense… Expand
  • 467
  • 44
  • Open Access
Multiple types of neuronal calcium channels and their selective modulation
Abstract Voltage-gated Ca 2+ channels control the entry of Ca 2+ ions across the surface membrane of neurons and other cells and thereby influence electrical activity and diverse cellular responses.… Expand
  • 1,380
  • 43