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IGK gene

Known as: Immunoglobulin Kappa Locus, IGK@, Kappa Light Chain Gene 
This region represents the germline organization of the kappa light chain locus. The locus includes V (variable), J (joining), and C (constant… 
National Institutes of Health

Related topics

Related topics

4 relations
2p12Humoral ImmunityImmune responseImmunoglobulin kappa-Chains

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2000
Highly Cited
2000
E2A and EBF act in synergy with the V(D)J recombinase to generate a diverse immunoglobulin repertoire in nonlymphoid cells.
Highly Cited
1996
Highly Cited
1996
Peripheral blood mononuclear cells of a patient with advanced Hodgkin's lymphoma give rise to permanently growing Hodgkin-Reed Sternberg cells.
A novel Hodgkin's disease (HD) derived cell line, L1236, was established from the peripheral blood of a patient with advanced… 
Highly Cited
1995
Highly Cited
1995
Light chain replacement: a new model for antibody gene rearrangement
A functional B cell antigen receptor is thought to regulate antibody gene rearrangement either by stopping further rearrangement… 
Review
1993
Review
1993
The variable genes of the human immunoglobulin kappa locus.
Highly Cited
1989
Highly Cited
1989
The immunoglobulin kappa locus contains a second, stronger B‐cell‐specific enhancer which is located downstream of the constant region.
The description of cell lines capable of transcribing immunoglobulin heavy or light chain genes in the apparent absence of an… 
Highly Cited
1984
Highly Cited
1984
Structure of the 5' ends of immunoglobulin genes: a novel conserved sequence.
Recent investigations have suggested that tissue-specific regulatory factors are required for immunoglobulin gene transcription… 
Highly Cited
1983
Highly Cited
1983
Clusters of point mutations are found exclusively around rearranged antibody variable genes.
We have examined the nucleotide sequences of a series of murine antibody genes derived from one kappa light chain gene in order… 
Highly Cited
1983
Highly Cited
1983
Translocation of an immunoglobulin kappa locus to a region 3' of an unrearranged c-myc oncogene enhances c-myc transcription.
We have studied somatic cell hybrids between mouse myeloma and JI Burkitt lymphoma cells carrying a t(2;8) chromosome… 
Highly Cited
1983
Highly Cited
1983
Intracisternal A-particle genes as movable elements in the mouse genome.
We analyzed two functionally defective mouse kappa light chain gene variants previously shown to contain novel insertions of… 
Highly Cited
1981
Highly Cited
1981
Developmental hierarchy of immunoglobulin gene rearrangements in human leukemic pre-B-cells.
We have used a special class of human acute lymphocytic leukemias, the common "non-T/non-B" cell type, to define a hierarchy of… 
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