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An inhibitor of Bcl-2 family proteins induces regression of solid tumours
Proteins in the Bcl-2 family are central regulators of programmed cell death, and members that inhibit apoptosis, such as Bcl-XL and Bcl-2, are overexpressed in many cancers and contribute to tumour… Expand
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death
Bcl-2 protein is able to repress a number of apoptotic death programs. To investigate the mechanism of Bcl-2's effect, we examined whether Bcl-2 interacted with other proteins. We identified an… Expand
Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death
Multiple death signals influence mitochondria during apoptosis, yet the critical initiating event for mitochondrial dysfunction in vivo has been unclear. tBID, the caspase-activated form of a… Expand
Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL
Extracellular survival factors alter a cell's susceptibility to apoptosis, often through posttranslational mechanisms. However, no consistent relationship has been established between such survival… Expand
BCL-2 family members and the mitochondria in apoptosis.
A variety of physiological death signals, as well as pathological cellular insults, trigger the genetically programmed pathway of apoptosis (Vaux and Korsmeyer 1999). Apoptosis manifests in two major… Expand
Cell Death Critical Control Points
Programmed cell death is a distinct genetic and biochemical pathway essential to metazoans. An intact death pathway is required for successful embryonic development and the maintenance of normal… Expand
Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics.
- A. Letai, M. Bassik, L. Walensky, Mia D Sorcinelli, S. Weiler, S. Korsmeyer
- Biology, Medicine
- Cancer cell
- 1 September 2002
The "BH3-only" proteins of the BCL-2 family require "multidomain" proapoptotic members BAX and BAK to release cytochrome c from mitochondria and kill cells. We find short peptides representing the… Expand
MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia
Acute lymphoblastic leukemias carrying a chromosomal translocation involving the mixed-lineage leukemia gene (MLL, ALL1, HRX) have a particularly poor prognosis. Here we show that they have a… Expand
BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis.
Critical issues in apoptosis include the importance of caspases versus organelle dysfunction, dominance of anti- versus proapoptotic BCL-2 members, and whether commitment occurs upstream or… Expand
Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death
- E. Yang, Jiping Zha, J. Jockel, L. Boise, C. Thompson, S. Korsmeyer
- Biology, Medicine
- 27 January 1995
To extend the mammalian cell death pathway, we screened for further Bcl-2 interacting proteins. Both yeast two-hybrid screening and lambda expression cloning identified a novel interacting protein,… Expand