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Proceedings of the National Academy of Sciences of the United States of America. Annual subject and author indexes.
This dissertation aims to provide a history of web exceptionalism from 1989 to 2002, a period chosen in order to explore its roots as well as specific cases up to and including the year in which descriptions of “Web 2.0” began to circulate. Expand
The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design
  • T. Waldmann
  • Biology, Medicine
  • Nature Reviews Immunology
  • 1 August 2006
The biology of these cytokines will affect the development of novel therapies for malignancy and autoimmune diseases, as well as the design of vaccines against infectious diseases. Expand
Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics
High-throughput RNA sequencing and RNA interference screening is used to discover essential regulatory pathways in Burkitt's lymphoma that cooperate with MYC, the defining oncogene of this cancer. Expand
Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells.
T tumor-reactive CD8+ T cell populations with the phenotypic and functional attributes of T(CM) may be superior to T(EM)/effector T cells for adoptive immunotherapies using concomitant tumor-antigen vaccination. Expand
IL-15Rα Recycles and Presents IL-15 In trans to Neighboring Cells
These complexes on activated monocytes present IL-15 in trans to target cells such as CD8 + T cells that express only IL-2/15Rβ and γc upon cell-cell interaction and contribute to the long survival of T cells expressing IL- 15Rα afterIL-15 withdrawal. Expand
The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens.
Abnormalities of IL-15 expression have been described in patients with rheumatoid arthritis or inflammatory bowel disease and in diseases associated with the retroviruses HIV and HTLV-I. Expand
Regulatory CD56(bright) natural killer cells mediate immunomodulatory effects of IL-2Ralpha-targeted therapy (daclizumab) in multiple sclerosis.
The data support the existence of an immunoregulatory pathway wherein activated CD56(bright) NK cells inhibit T cell survival and has potential importance for the treatment of autoimmune diseases and transplant rejection and toward modification of tumor immunity. Expand
IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells.
These complexes on activated monocytes present IL-15 in trans to target cells such as CD8(+) T cells that express only IL-2/15Rbeta and gammac upon cell-cell interaction. Expand
Exploiting synthetic lethality for the therapy of ABC diffuse large B cell lymphoma.
Blockade of B cell receptor signaling using the BTK inhibitor ibrutinib also downregulates IRF4 and consequently synergizes with lenalidomide in killing ABC DLBCLs, suggesting attractive therapeutic strategies. Expand
Contrasting roles of IL-2 and IL-15 in the life and death of lymphocytes: implications for immunotherapy.
This work concludes that IL-15 with its inhibitory action on AICD and its stimulatory role in the persistence of memory CD8+ T cells may be superior to IL-2 in the treatment of cancer and as a component of vaccines directed toward cancer or infectious agents. Expand