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Mice Lacking p21 CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
TLDR
The results establish the role of p21CIP1/WAF1 in the G1 checkpoint, but suggest that the anti-apoptotic and theAnti-oncogenic effects of p53 are more complex. Expand
Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance.
TLDR
It is demonstrated that LDH-A plays a key role in tumor maintenance as well as stimulation of mitochondrial respiration and decrease of mitochondrial membrane potential in malignant cells. Expand
Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene
TLDR
The results indicate that the combination of activated oncogene and tissue context are major determinants of malignant progression and that expression of the activated form of c-neu in the mammary epithelium has particularly deleterious consequences. Expand
RIP: A novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death
TLDR
Transient overexpression of RIP causes transfected cells to undergo the morphological changes characteristic of apoptosis, and these properties indicate that RIP is a novel form of apoptotic-inducing protein. Expand
Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose.
  • H. Aviv, P. Leder
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 June 1972
TLDR
A convenient technique for the partial purification of large quantities of functional, poly(adenylic acid)-rich mRNA is described and should prove generally useful as an initial step in the isolation of specific mRNAs. Expand
Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction.
TLDR
Findings provide direct genetic evidence that FGF/FGFR2 signals are absolutely required for vertebrate limb induction and that an FGFR2 signal is essential for the reciprocal regulation loop between FGF8 and FGF10 during limb induction. Expand
Fibroblast Growth Factor Receptor 3 Is a Negative Regulator of Bone Growth
TLDR
FGFR-3 appears to regulate endochondral ossification by an essentially negative mechanism, limiting rather than promoting osteogenesis, and certain human disorders, such as achondroplasia, can be interpreted as gain-of-function mutations that activate the fundamentally negative growth control exerted by the FGFR- 3 kinase. Expand
Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor
TLDR
It is demonstrated that free heparin and heparan sulfate can reconstitute a low affinity receptor that is, in turn, required for the high affinity binding of bFGF. Expand
A maternal-zygotic effect gene, Zfp57, maintains both maternal and paternal imprints.
TLDR
Intriguingly, methylation imprints are reacquired specifically at the maternally derived Snrpn imprinted region when the zygotic Zfp57 is present in embryos, suggesting that there may be DNA methylation-independent memory for genomic imprints. Expand
Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: Synergistic action of oncogenes in vivo
TLDR
Since these tumors arise stochastically and are apparently monoclonal in origin, additional somatic events appear necessary for their full malignant progression, even in the presence of activated v-Ha-ras and c-myc transgenes. Expand
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