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Histidine-tRNA Ligase

Known as: Jo 1 Antigen, Histidyl tRNA Synthetase, Ligase, His-tRNA 
An enzyme that activates histidine with its specific transfer RNA. EC 6.1.1.21.
National Institutes of Health

Related topics

Related topics

8 relations
HARS geneIn BloodProcess of secretionantagonists & inhibitors

Papers overview

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Highly Cited
2010
Highly Cited
2010
Interference with histidyl-tRNA synthetase by a CRISPR spacer sequence as a factor in the evolution of Pelobacter carbinolicus
BackgroundPelobacter carbinolicus, a bacterium of the family Geobacteraceae, cannot reduce Fe(III) directly or produce… 
Highly Cited
2000
Highly Cited
2000
A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha.
A family of protein kinases regulates translation in response to different cellular stresses by phosphorylation of the alpha… 
Highly Cited
1997
Highly Cited
1997
Crystal structure analysis of the activation of histidine by Thermus thermophilus histidyl-tRNA synthetase.
The crystal structure at 2.7 A resolution of histidyl-tRNA synthetase (HisRS) from Thermus thermophilus in complex with its amino… 
Highly Cited
1997
Highly Cited
1997
The first step of aminoacylation at the atomic level in histidyl-tRNA synthetase.
The crystal structure of an enzyme-substrate complex with histidyl-tRNA synthetase from Escherichia coli, ATP, and the amino acid… 
Highly Cited
1994
Highly Cited
1994
A motif in human histidyl-tRNA synthetase which is shared among several aminoacyl-tRNA synthetases is a coiled-coil that is essential for enzymatic activity and contains the major autoantigenic…
Highly Cited
1994
Highly Cited
1994
A broadened spectrum of juvenile myositis. Myositis-specific autoantibodies in children.
OBJECTIVE Myositis-specific autoantibodies (MSA) define relatively homogeneous clinical and immunogenetic patient groups in… 
Highly Cited
1992
Highly Cited
1992
Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases
The protein kinase GCN2 stimulates expression of the yeast transcriptional activator GCN4 at the translational level by… 
Highly Cited
1972
Highly Cited
1972
[Mutant tRNA His ineffective in repression and lacking two pseudouridine modifications].
TRANSFER RNA has been implicated in the regulation of a number of amino-acid biosynthetic operons1–4. Histidyl-tRNAHis has been… 
Highly Cited
1966
Highly Cited
1966
Histidine regulatory mutants in Salmonella typhimurium. I. Isolation and general properties.
Highly Cited
1966
Highly Cited
1966
Histidine regulatory mutants in Salmonella typhimurium II. Histidine regulatory mutants having altered histidyl-tRNA synthetase.
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