Skip to search formSkip to main contentSkip to account menu
  • Publications
  • Influence
The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus
TLDR
It is discovered that the hepatitis C virus (HCV) envelope glycoprotein E2 binds to human hepatoma cell lines independently of the previously proposed HCV receptor CD81, and the receptor responsible for E2 binding to human hepatic cells is identified as the human scavenger receptor class B type I (SR‐BI).
View on Wiley
Cell Entry of Hepatitis C Virus Requires a Set of Co-receptors That Include the CD81 Tetraspanin and the SR-B1 Scavenger Receptor*
TLDR
It is shown that HCV is a pH-dependent virus, implying that its receptor component(s) mediate virion internalization by endocytosis, and suggested that, besides CD81 and SR-B1, additional hepatocyte-specific co-factor(S) are necessary for HCV entry.
View on Publisher
The crystal structure of the quorum sensing protein TraR bound to its autoinducer and target DNA
TLDR
The crystal structure of TraR, the transcriptional regulator involved in quorum sensing of Agrobacterium tumefaciens, is determined and reveals an asymmetric homodimer, with one monomer longer than the other.
View on Wiley
Characterization of Resistance to Non-obligate Chain-terminating Ribonucleoside Analogs That Inhibit Hepatitis C Virus Replication in Vitro*
TLDR
2′-C-methyl-substituted ribonucleosides are efficient chain-terminating inhibitors of HCV genome replication and the combination of these agents with interferon-α results in synergistic inhibition of HCv genome replication in cell culture.
View on Publisher
IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to C EBP
View on Elsevier
Novel Adenovirus-Based Vaccines Induce Broad and Sustained T Cell Responses to HCV in Man
TLDR
It is demonstrated that vaccines developed with adenoviral vectors can induce broad and sustained immune responses to HCV in humans and open the way for studies of prophylactic and therapeutic vaccines for HCV.
View on Publisher
Chimpanzee adenovirus vaccine generates acute and durable protective immunity against ebolavirus challenge
TLDR
It is shown that a chimpanzee-derived replication-defective adenovirus (ChAd) vaccine also rapidly induced uniform protection against acute lethal EBOV challenge in macaques, and generated, for the first time, durable protection against lethal E BOV challenge.
View on Nature
pEMBL: a new family of single stranded plasmids.
TLDR
These vectors have been used successfully for DNA sequencing with the dideoxy-method, and can be used for any other purpose for which M13 derivatives are used, however, the pEMBL plasmids have the advantage of being smaller than M13 vectors, and the purification of the DNA is simpler.
View on PubMed
The liver-specific transcription factor LF-B1 contains a highly diverged homeobox DNA binding domain
View on Elsevier
A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase.
TLDR
These studies provide a structural basis and rationale for developing integrase inhibitors with the potential for unique and nonoverlapping resistance profiles and propose a model of the two inhibitors that is consistent with this observation and suggests specific interactions with discrete binding sites for each ligand.
View on PubMed
...
...
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License