A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha.

@article{Sood2000AMH,
  title={A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha.},
  author={Ruchira Sood and Amy C. Porter and Dorte Aa Olsen and Douglas R Cavener and Ronald C Wek},
  journal={Genetics},
  year={2000},
  volume={154 2},
  pages={
          787-801
        }
}
A family of protein kinases regulates translation in response to different cellular stresses by phosphorylation of the alpha subunit of eukaryotic initiation factor-2 (eIF-2alpha). In yeast, an eIF-2alpha kinase, GCN2, functions in translational control in response to amino acid starvation. It is thought that uncharged tRNA that accumulates during amino acid limitation binds to sequences in GCN2 homologous to histidyl-tRNA synthetase (HisRS) enzymes, leading to enhanced kinase catalytic… CONTINUE READING

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