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Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets
TLDR
Recent advances in understanding of the molecular structures and biochemical functions of the translation initiation machinery are described and key strategies that mediate general or gene-specific translational control are summarized, particularly in mammalian systems. Expand
Translational regulation of GCN4 and the general amino acid control of yeast.
  • A. Hinnebusch
  • Biology, Medicine
  • Annual review of microbiology
  • 9 September 2005
TLDR
M mammalian cells use the same strategy to downregulate protein synthesis while inducing transcriptional activators of stress-response genes under various stressful conditions, including amino acid starvation. Expand
Transcriptional Profiling Shows that Gcn4p Is a Master Regulator of Gene Expression during Amino Acid Starvation in Yeast
TLDR
The broad transcriptional response evoked by Gcn4p is produced by diverse stress conditions, and numerous genes encoding protein kinases and transcription factors were identified as targets, suggesting that Gcn 4p is a master regulator of gene expression. Expand
The scanning mechanism of eukaryotic translation initiation.
  • A. Hinnebusch
  • Biology, Medicine
  • Annual review of biochemistry
  • 6 June 2014
In eukaryotes, the translation initiation codon is generally identified by the scanning mechanism, wherein every triplet in the messenger RNA leader is inspected for complementarity to the anticodonExpand
Translational control by 5′-untranslated regions of eukaryotic mRNAs
TLDR
Various mechanisms controlling ribosome scanning and initiation codon selection by 5′ upstream open reading frames, translation initiation factors, and primary and secondary structures of the 5′UTR, including particular sequence motifs are described. Expand
Phosphorylation of the Pol II CTD by KIN28 enhances BUR1/BUR2 recruitment and Ser2 CTD phosphorylation near promoters.
TLDR
It is shown that BUR1/BUR2 is cotranscriptionally recruited to the 5' end of ARG1 in a manner stimulated by interaction of the BUR1 C terminus with CTD repeats phosphorylated on Ser5 by KIN28. Expand
The mechanism of eukaryotic translation initiation: new insights and challenges.
TLDR
The current understanding of the molecular mechanics of eukaryotic translation initiation is reviewed, focusing on recent breakthroughs from in vitro and in vivo studies. Expand
Translational Regulation of Yeast GCN4
  • A. Hinnebusch
  • Chemistry, Medicine
  • The Journal of Biological Chemistry
  • 29 August 1997
TLDR
Disclosed is a pneumatic launch apparatus which employs separable telescoping tubes which automatically close upon separation of the tubes to trap operating gas in the tubes at the moment of separation. Expand
Phosphorylation of initiation factor 2α by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast
TLDR
An established mechanism for regulating total protein synthesis in mammalian cells mediates gene-specific translational control in yeast through phosphorylation of the alpha subunit of eIF-2 by the protein kinase GCN2. Expand
eIF3: a versatile scaffold for translation initiation complexes.
  • A. Hinnebusch
  • Biology, Medicine
  • Trends in biochemical sciences
  • 1 October 2006
TLDR
Structural analysis suggests that the location of eIF3 seems ideally suited for its other proposed regulatory functions, including reinitiating translation on polycistronic mRNAs and acting as a receptor for protein kinases that control protein synthesis. Expand
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