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Revised methods for the Salmonella mutagenicity test.
The free radical theory of aging matures.
The status of the free radical theory of aging is reviewed, by categorizing the literature in terms of the various types of experiments that have been performed, which include phenomenological measurements of age-associated oxidative stress, interspecies comparisons, dietary restriction, and the ongoing elucidation of the role of active oxygen in biology.
Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test.
Oxidants, antioxidants, and the degenerative diseases of aging.
- B. Ames, M. Shigenaga, T. Hagen
- MedicineProceedings of the National Academy of Sciences…
- 1 September 1993
It is argued that this damage to DNA, protein, and lipid is a major contributor to aging and to degenerative diseases of aging such as cancer, cardiovascular disease, immune-system decline, brain dysfunction, and cataracts.
ASSAY OF INORGANIC PHOSPHATE, TOTAL PHOSPHATE AND PHOSPHATASE
- B. Ames
Bilirubin is an antioxidant of possible physiological importance.
The data support the idea of a "beneficial" role for bilirubin as a physiological, chain-breaking antioxidant.
Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage.
Both high DNA uracil levels and elevated micronucleus frequency (a measure of chromosome breaks) are reversed by folate administration, which could contribute to the increased risk of cancer and cognitive defects associated with folate deficiency in humans.
Normal oxidative damage to mitochondrial and nuclear DNA is extensive.
- C. Richter, J. Park, B. Ames
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 1 September 1988
The oxidized base, 8-hydroxydeoxyguanosine (oh8dG), 1 of approximately 20 known radiation damage products, has been assayed in the DNA of rat liver and may be responsible for the observed high mutation rate of mtDNA.
Positive control of a regulon for defenses against oxidative stress and some heat-shock proteins in Salmonella typhimurium
Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis.
- B. Ames, R. Cathcart, E. Schwiers, P. Hochstein
- BiologyProceedings of the National Academy of Sciences…
- 1 November 1981
It is shown that, at physiological concentrations, urate reduces the oxo-heme oxidant formed by peroxide reaction with hemoglobin, protects erythrocyte ghosts against lipid peroxidation, and protects ERYthrocytes from peroxidative damage leading to lysis.