Heterodimerization

Heterodimerization involves a biophysical interaction between two dissimilar biological molecules or subunits, such as between two proteins. The… (More)
National Institutes of Health

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Topic mentions per year

1990-2018
05101519902018

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Highly Cited
2006
Highly Cited
2006
The Ras-Raf-MEK-extracellular signal-regulated kinase (ERK) pathway participates in the control of many fundamental cellular… (More)
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Highly Cited
2006
Highly Cited
2006
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have been used to treat non-small cell lung cancer… (More)
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Highly Cited
2004
Highly Cited
2004
In Arabidopsis thaliana brassinosteroid (BR), perception is mediated by two Leu-rich repeat receptor-like kinases… (More)
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Highly Cited
2001
Highly Cited
2001
Chemokine receptors of both the CC and CXC families have been demonstrated to undergo a ligand-mediated homodimerization process… (More)
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Highly Cited
2000
Highly Cited
2000
Surface expression of GABA(B) receptors requires heterodimerization of GB1 and GB2 subunits, but little is known about mechanisms… (More)
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Highly Cited
2000
Highly Cited
2000
Opiate analgesics are widely used in the treatment of severe pain. Because of their importance in therapy, different strategies… (More)
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Highly Cited
1998
Highly Cited
1998
GABA (gamma-aminobutyric acid) is the main inhibitory neurotransmitter in the mammalian central nervous system, where it exerts… (More)
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Highly Cited
1997
Highly Cited
1997
We have analyzed ErbB receptor interplay induced by the epidermal growth factor (EGF)-related peptides in cell lines naturally… (More)
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Highly Cited
1993
Highly Cited
1993
Ecdysone in Drosophila has been a paradigm for steroid hormones since its ability to induce gene activity directly was… (More)
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Highly Cited
1993
Highly Cited
1993
The E2F transcription factor has been implicated in the regulation of genes whose products are involved in cell proliferation… (More)
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