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Heterodimerization

Heterodimerization involves a biophysical interaction between two dissimilar biological molecules or subunits, such as between two proteins. The… Expand
National Institutes of Health

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Related topics

9 relations
ID3 geneITGA4 geneITGA4 wt AlleleITGA6 gene
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Papers overview

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Highly Cited
2006
Highly Cited
2006
Regulation and Role of Raf-1/B-Raf Heterodimerization
ABSTRACT The Ras-Raf-MEK-extracellular signal-regulated kinase (ERK) pathway participates in the control of many fundamental… Expand
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Review
2005
Review
2005
Emerging role of homo- and heterodimerization in G-protein-coupled receptor biosynthesis and maturation.
The idea that G-protein-coupled receptors (GPCRs) can function as dimers is now generally accepted. Although an increasing amount… Expand
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Highly Cited
2005
Highly Cited
2005
Odorant receptor heterodimerization in the olfactory system of Drosophila melanogaster
Despite increasing knowledge about dimerization of G-protein-coupled receptors, nothing is known about dimerization in the… Expand
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Highly Cited
2000
Highly Cited
2000
A Trafficking Checkpoint Controls GABAB Receptor Heterodimerization
Surface expression of GABA(B) receptors requires heterodimerization of GB1 and GB2 subunits, but little is known about mechanisms… Expand
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Highly Cited
1999
Highly Cited
1999
G-protein-coupled receptor heterodimerization modulates receptor function
The opioid system modulates several physiological processes, including analgesia, the stress response, the immune response and… Expand
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Highly Cited
1997
Highly Cited
1997
ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling.
We have analyzed ErbB receptor interplay induced by the epidermal growth factor (EGF)-related peptides in cell lines naturally… Expand
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Highly Cited
1996
Highly Cited
1996
Identification of a natural soluble form of the vascular endothelial growth factor receptor, FLT-1, and its heterodimerization with KDR.
A soluble form of the vascular endothelial growth factor (VEGF) receptor FLT-1 was identified in conditioned culture medium of… Expand
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Highly Cited
1996
Highly Cited
1996
'Knobs-into-holes' engineering of antibody CH3 domains for heavy chain heterodimerization.
'Knobs-into-holes' was originally proposed by Crick in 1952 as a model for the packing of amino acid side chains between adjacent… Expand
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Highly Cited
1995
Highly Cited
1995
A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1.
In addition to its role as a 9-cis retinoic acid receptor, RXR has an important role in the regulation of multiple hormonal… Expand
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Highly Cited
1994
Highly Cited
1994
BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax
BCL-2 was isolated from the t(14;18) chromosomal breakpoint in follicular B-cell lymphoma1–3. Bcl-2 has the unique oncogenic role… Expand
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