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Heterodimerization

Heterodimerization involves a biophysical interaction between two dissimilar biological molecules or subunits, such as between two proteins. The… 
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
ABSTRACT The Ras-Raf-MEK-extracellular signal-regulated kinase (ERK) pathway participates in the control of many fundamental… 
Review
2005
Review
2005
G protein-coupled receptors (GPCRs) are cell surface receptors that mediate physiological responses to a diverse array of stimuli… 
Highly Cited
2001
Highly Cited
2001
Chemokine receptors of both the CC and CXC families have been demonstrated to undergo a ligand‐mediated homodimerization process… 
Review
2000
Review
2000
Cells are continuously exposed to diverse stimuli ranging from soluble endocrine and paracrine factors, to signaling molecules on… 
Highly Cited
1999
Highly Cited
1999
The opioid system modulates several physiological processes, including analgesia, the stress response, the immune response and… 
Highly Cited
1997
Highly Cited
1997
We have analyzed ErbB receptor interplay induced by the epidermal growth factor (EGF)‐related peptides in cell lines naturally… 
Highly Cited
1996
Highly Cited
1996
'Knobs-into-holes' was originally proposed by Crick in 1952 as a model for the packing of amino acid side chains between adjacent… 
Highly Cited
1996
Highly Cited
1996
A soluble form of the vascular endothelial growth factor (VEGF) receptor FLT-1 was identified in conditioned culture medium of… 
Highly Cited
1994
Highly Cited
1994
BCL-2 was isolated from the t(14;18) chromosomal breakpoint in follicular B-cell lymphoma1–3. Bcl-2 has the unique oncogenic role…