Histone Deacetylase (HDAC) Activity Is Critical for Embryonic Kidney Gene Expression, Growth, and Differentiation*
- Shaowei Chen, Christine Bellew, S. El-Dahr
- BiologyJournal of Biological Chemistry
- 21 July 2011
It is concluded that HDAC activity is critical for normal embryonic kidney homeostasis, and class I HDACs are implicate in the regulation of early nephron gene expression, differentiation, and survival.
Ontogeny of somatic angiotensin-converting enzyme.
- I. Yosipiv, S. Dipp, S. El-Dahr
- BiologyHYPERTENSION
- 1 March 1994
It is demonstrated that the ACE-KII gene is developmentally regulated in a tissue-specific manner and correlated temporally with changes in circulating angiotensin II and tissue kallikrein.
ECM degradation by cultured human mesangial cells is mediated by a PA/plasmin/MMP-2 cascade.
- W. Baricos, S. Cortez, S. El-Dahr, H. Schnaper
- BiologyKidney International
- 1 April 1995
The role of the plasminogen activator/plasmin system in extracellular matrix (ECM) degradation by human mesangial cells cultured on thin films of 125I-labeled ECM (Matrigel) was examined and latent matrix metalloproteinase-2 (MMP-2) which was converted to a lower molecular weight, active form in the presence of mesangia cells and plasmineogen.
Augmentation of intrarenal angiotensin II levels by chronic angiotensin II infusion.
- A. V. von Thun, R. Vari, S. El-Dahr, L. Navar
- BiologyAmerican Journal of Physiology
- 1994
The objective of this study was to investigate the singular role of elevated angiotensin II (ANG II) levels in the development of two-kidney, one-clip (2K1C) Goldblatt hypertension in the rat and…
Mechanisms of Disease: the tissue kallikrein–kinin system in hypertension and vascular remodeling
- P. Madeddu, C. Emanueli, S. El-Dahr
- Medicine, BiologyNature Clinical Practice Nephrology
- 1 April 2007
Development of novel therapeutic approaches to bolster kinin activity in the vascular wall and in specific compartments in the kidney might be a highly effective strategy for the treatment of hypertension and its complications, including cardiac hypertrophy and renal failure.
Cross-talk of the renin-angiotensin and kallikrein-kinin systems
- B. Shen, S. El-Dahr
- BiologyBiological chemistry
- 1 February 2006
Recent knowledge regarding interactions at the cellular and molecular levels between the RAS and KKS systems are highlighted, with an emphasis on the coordinate developmental regulation of these phylogenetically conserved vasoactive systems.
Spatial repression of PCNA by p53 during kidney development.
- Z. Saifudeen, Jessica R. Marks, H. Du, S. El-Dahr
- BiologyAJP - Renal Physiology
- 1 October 2002
The hypothesis that p53-mediated transcriptional repression plays a role in the spatial restriction of PCNA gene expression during normal renal development is proposed.
Immunohistochemical localization of ANG II AT1 receptor in adult rat kidney using a monoclonal antibody.
- L. Harrison-Bernard, L. G. Navar, M. M. Ho, G. Vinson, S. El-Dahr
- BiologyAmerican Journal of Physiology
- 1 July 1997
The present study demonstrates that the AT1 receptor is more widely distributed along the nephron than previously described and includes renal vascular smooth muscle and proximal and distal epithelial sites.
Hypoxia Induces Selective SAPK/JNK‐2‐AP‐1 Pathway Activation in the Nucleus Tractus Solitarii of the Conscious Rat
- E. Gozal, N. Simakajornboon, D. Gozal
- BiologyJournal of Neurochemistry
- 1 August 1999
In conscious rats, a moderate hypoxic stimulus elicits NMDA‐dependent widespread mitogenactivated protein kinase activation in cortex, but selective SAPK/JNK‐2 and AP‐1 activation in the nucleus tractus solitarii, thereby suggesting a functional role for the SAPK‐2‐AP‐1 pathway.
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