The hormone resistin links obesity to diabetes
- C. Steppan, S. Bailey, M. Lazar
- Medicine, BiologyNature
- 18 January 2001
It is shown that adipocytes secrete a unique signalling molecule, which is named resistin (for resistance to insulin), which circulating resistin levels are decreased by the anti-diabetic drug rosiglitazone, and increased in diet-induced and genetic forms of obesity.
Histone Deacetylase Is a Direct Target of Valproic Acid, a Potent Anticonvulsant, Mood Stabilizer, and Teratogen*
- C. Phiel, Fang Zhang, E. Huang, M. Guenther, M. Lazar, P. S. Klein
- BiologyJournal of Biological Chemistry
- 28 September 2001
It is proposed that inhibition of histone deacetylase provides a mechanism for valproic acid-induced birth defects and could also explain the efficacy of valproIC acid in the treatment of bipolar disorder.
Cofactor Dynamics and Sufficiency in Estrogen Receptor–Regulated Transcription
- Y. Shang, Xiao Hu, J. Direnzo, M. Lazar, Myles A Brown
- BiologyCell
- 8 December 2000
Forming functional fat: a growing understanding of adipocyte differentiation
- Ana G. Cristancho, M. Lazar
- BiologyNature reviews. Molecular cell biology
- 1 November 2011
Improving the understanding of these mechanisms may allow us to identify therapeutic targets against metabolic diseases that are rapidly becoming epidemic globally.
Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR.
- W. Fischle, F. Dequiedt, E. Verdin
- BiologyMolecules and Cells
- 2002
A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness.
- M. Guenther, William Arbuthnot Sir Lane, W. Fischle, E. Verdin, M. Lazar, R. Shiekhattar
- BiologyGenes & Development
- 1 May 2000
This work reports the isolation of a novel SMRT-containing complex from HeLa cells that contains transducin beta-like protein 1 (TBL1), whose gene is mutated in human sensorineural deafness and contains HDAC3, a histone deacetylase not previously thought to interact with SMRT.
A novel role for thyroid hormone, glucocorticoids and retinoic acid in timing oligodendrocyte development.
It is shown here that this clock mechanism can be separated into a counting component and an effector component that stops cell proliferation: whereas the counting mechanism is driven by mitogens that activate cell-surface receptors, the effector mechanism depends on hydrophobic signals that activate intracellular receptors, such as thyroid hormones, glucocorticoids and retinoic acid.
New developments in adipogenesis
- M. Lefterova, M. Lazar
- BiologyTrends in endocrinology and metabolism
- 1 April 2009
PPARgamma and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale.
- M. Lefterova, Yong Zhang, M. Lazar
- BiologyGenes & Development
- 1 November 2008
Peroxisome proliferator-activated receptor gamma (PPARgamma), a nuclear receptor and the target of anti-diabetic thiazolinedione drugs, and C/EBPbeta also plays a role at many of these genes, such that both C/EBPalpha and beta are required along with PPARGamma for robust adipocyte-specific gene expression.
A family of tissue-specific resistin-like molecules.
- C. Steppan, E. Brown, M. Lazar
- BiologyProceedings of the National Academy of Sciences…
- 16 January 2001
The RELMs together with resistin comprise a class of tissue-specific signaling molecules that share a cysteine composition and other signature features and suggest a role in intestinal proliferation.
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