M. Lazar

Publications313
h-index121
Citations55,912
Highly Influential Citations2,572
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The hormone resistin links obesity to diabetes
Diabetes mellitus is a chronic disease that leads to complications including heart disease, stroke, kidney failure, blindness and nerve damage. Type 2 diabetes, characterized by target-tissue… Expand
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  • 232
Histone Deacetylase Is a Direct Target of Valproic Acid, a Potent Anticonvulsant, Mood Stabilizer, and Teratogen*
Valproic acid is widely used to treat epilepsy and bipolar disorder and is also a potent teratogen, but its mechanisms of action in any of these settings are unknown. We report that valproic acid… Expand
  • 1,520
  • 86
Cofactor Dynamics and Sufficiency in Estrogen Receptor–Regulated Transcription
Many cofactors bind the hormone-activated estrogen receptor (ER), yet the specific regulators of endogenous ER-mediated gene transcription are unknown. Using chromatin immunoprecipitation (ChIP), we… Expand
  • 1,652
  • 75
  • PDF
Forming functional fat: a growing understanding of adipocyte differentiation
Adipose tissue, which is primarily composed of adipocytes, is crucial for maintaining energy and metabolic homeostasis. Adipogenesis is thought to occur in two stages: commitment of mesenchymal stem… Expand
  • 900
  • 66
Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR.
Histone deacetylases (HDACs) play a key role in regulating eukaryotic gene expression. The HDAC domain, homologous to the yeast repressors RPD3 and HDA1, is considered necessary and sufficient for… Expand
  • 691
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A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness.
The corepressor SMRT mediates repression by thyroid hormone receptor (TR) as well as other nuclear hormone receptors and transcription factors. Here we report the isolation of a novel SMRT-containing… Expand
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  • PDF
PPARgamma and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale.
Peroxisome proliferator-activated receptor gamma(PPARgamma), a nuclear receptor and the target of anti-diabetic thiazolinedione drugs, is known as the master regulator of adipocyte biology. Although… Expand
  • 595
  • 47
A family of tissue-specific resistin-like molecules.
We have identified a family of resistin-like molecules (RELMs) in rodents and humans. Resistin is a hormone produced by fat cells. RELMalpha is a secreted protein that has a restricted tissue… Expand
  • 591
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  • PDF
Thyroid hormone receptors: multiple forms, multiple possibilities.
  • M. Lazar
  • Biology, Medicine
  • Endocrine reviews
  • 1 April 1993
I. Introduction THE biological importance of the thyroid gland has been recognized for centuries (1). The realization in the late 19th century that cretinism and myxedema result from loss of thyroid… Expand
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The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors
N-CoR and SMRT are transcriptional corepressors that associate with nuclear hormone receptors (NRs) in the absence of ligand. This interaction is the molecular target of differentiation therapy for… Expand
  • 622
  • 41