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The hormone resistin links obesity to diabetes
It is shown that adipocytes secrete a unique signalling molecule, which is named resistin (for resistance to insulin), which circulating resistin levels are decreased by the anti-diabetic drug rosiglitazone, and increased in diet-induced and genetic forms of obesity. Expand
Histone Deacetylase Is a Direct Target of Valproic Acid, a Potent Anticonvulsant, Mood Stabilizer, and Teratogen*
- C. Phiel, Fang Zhang, E. Huang, M. Guenther, M. Lazar, P. S. Klein
- Medicine, Chemistry
- The Journal of Biological Chemistry
- 28 September 2001
It is proposed that inhibition of histone deacetylase provides a mechanism for valproic acid-induced birth defects and could also explain the efficacy of valproIC acid in the treatment of bipolar disorder. Expand
Cofactor Dynamics and Sufficiency in Estrogen Receptor–Regulated Transcription
It is shown that recruitment of the p160 class of coactivators is sufficient for gene activation and for the growth stimulatory actions of estrogen in breast cancer supporting a model in which ER cofactors play unique roles in estrogen signaling. Expand
Forming functional fat: a growing understanding of adipocyte differentiation
Improving the understanding of these mechanisms may allow us to identify therapeutic targets against metabolic diseases that are rapidly becoming epidemic globally. Expand
PPARgamma and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale.
Peroxisome proliferator-activated receptor gamma (PPARgamma), a nuclear receptor and the target of anti-diabetic thiazolinedione drugs, and C/EBPbeta also plays a role at many of these genes, such that both C/EBPalpha and beta are required along with PPARGamma for robust adipocyte-specific gene expression. Expand
Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR.
It is shown that the catalytic domain of HDAC4 interacts with HDAC3 via the transcriptional corepressor N-CoR/SMRT, which indicates that class II HDACs regulate transcription by bridging the enzymatically active SMRT/N- CoR-HDAC3 complex and select transcription factors independently of any intrinsic HDAC activity. Expand
A novel role for thyroid hormone, glucocorticoids and retinoic acid in timing oligodendrocyte development.
It is shown here that this clock mechanism can be separated into a counting component and an effector component that stops cell proliferation: whereas the counting mechanism is driven by mitogens that activate cell-surface receptors, the effector mechanism depends on hydrophobic signals that activate intracellular receptors, such as thyroid hormones, glucocorticoids and retinoic acid. Expand
A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness.
- M. Guenther, William Arbuthnot Sir Lane, W. Fischle, E. Verdin, M. Lazar, R. Shiekhattar
- Medicine, Biology
- Genes & development
- 1 May 2000
This work reports the isolation of a novel SMRT-containing complex from HeLa cells that contains transducin beta-like protein 1 (TBL1), whose gene is mutated in human sensorineural deafness and contains HDAC3, a histone deacetylase not previously thought to interact with SMRT. Expand
A family of tissue-specific resistin-like molecules.
- C. Steppan, E. Brown, +8 authors M. Lazar
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 16 January 2001
The RELMs together with resistin comprise a class of tissue-specific signaling molecules that share a cysteine composition and other signature features and suggest a role in intestinal proliferation. Expand
The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors
The key feature of hormone action, differential recognition of unliganded and liganded NRs by coactivators and corepressors, is due to very subtle differences between CoRNR and NR boxes. Expand