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HNF1A gene

Known as: ALBUMIN PROXIMAL FACTOR, LFB1, HNF1 Homeobox A Gene 
This gene plays a role in both DNA binding and transcriptional modulation.
National Institutes of Health

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HNF1A wt Allele
Hepatocyte Nuclear Factor 1Hepatocyte Nuclear Factor 1-alphaHomo sapiensTranscriptional Activation

Papers overview

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Highly Cited
2004
Highly Cited
2004
Messenger RNA transcripts of the hepatocyte nuclear factor-1alpha gene containing premature termination codons are subject to nonsense-mediated decay.
Mutations in the hepatocyte nuclear factor-1alpha (HNF-1a) gene cause maturity-onset diabetes of the young (MODY). Approximately… 
Highly Cited
2001
Highly Cited
2001
Inhibitory Cross-talk between STAT5b and Liver Nuclear Factor HNF3β
STAT5b is repeatedly activated in rodent liver by the male pattern of intermittent plasma growth hormone (GH) stimulation and is… 
2001
2001
The role of hepatic nuclear factor 1 alpha and PDX-1 in transcriptional regulation of the pdx-1 gene.
The PDX-1 homeodomain transcription factor regulates pancreatic development and adult islet beta cell function. Expression of the… 
1998
1998
HNF1 is critical for the liver-specific function of HBV enhancer II.
Highly Cited
1997
Highly Cited
1997
A hepatitis B virus mutant with a new hepatocyte nuclear factor 1 binding site emerging in transplant‐transmitted fulminant hepatitis B
Hepatitis B virus (HBV) DNA was cloned from serum of a heart transplant recipient who died from fulminant hepatitis B transmitted… 
1995
1995
Developmental expression of the maternal protein XDCoH, the dimerization cofactor of the homeoprotein LFB1 (HNF1).
The tissue-specific transcription factors LFB1 (HNF1) and LFB3 (vHNF1) mainly expressed in liver, kidney and intestine are… 
1995
1995
Three‐dimensional structure of the bifunctional protein PCD/DCoH, a cytoplasmic enzyme interacting with transcription factor HNF1.
The bifunctional protein pterin‐4a‐carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH) is a cytoplasmic enzyme… 
Highly Cited
1993
Highly Cited
1993
HNF4 and HNF1 as well as a panel of hepatic functions are extinguished and reexpressed in parallel in chromosomally reduced rat hepatoma-human fibroblast hybrids
Rat hepatoma-human fibroblast hybrids of two independent lineages containing only 8-11 human chromosomes show pleiotropic… 
Highly Cited
1990
Highly Cited
1990
Activation of octamer-containing promoters by either octamer-binding transcription factor 1 (OTF-1) or OTF-2 and requirement of an additional B-cell-specific component for optimal transcription of…
Several distinct octamer-binding transcription factors (OTFs) interact with the sequence ATTTGCAT (the octamer motif), which acts… 
Highly Cited
1990
Highly Cited
1990
Differentiation-specific transcriptional regulation of the hepatitis B virus large surface antigen gene in human hepatoma cell lines
The transcriptional activities of the four hepatitis B virus promoters were compared in three differentiated hepatoma cell lines… 
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