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Transcriptional Activation

Known as: Up-Regulation, Activation, Transcription, Transcription Activation 
The process by which an unexpressed gene is activated to serve as a transcription template for synthesis of RNA.
National Institutes of Health

Related topics

Related topics

50 relations
ARNTL geneAlpha-Globin Transcription Factor CP2CDK8 geneCREB1 protein, human

Papers overview

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Highly Cited
2005
Highly Cited
2005
β-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation
Wnt growth factors mediate cell fate determination during embryogenesis and in the renewal of tissues in the adult. Wnts act by… 
Highly Cited
2001
Highly Cited
2001
Methylation of Histone H4 at Arginine 3 Facilitating Transcriptional Activation by Nuclear Hormone Receptor
Acetylation of core histone tails plays a fundamental role in transcription regulation. In addition to acetylation, other… 
Highly Cited
1999
Highly Cited
1999
The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module.
Cytochrome P-450 3A4 (CYP3A4), the predominant cytochrome P-450 expressed in adult human liver, is subject to transcriptional… 
Highly Cited
1997
Highly Cited
1997
Hypoxia-inducible Factor-1 Mediates Transcriptional Activation of the Heme Oxygenase-1 Gene in Response to Hypoxia*
Exposure of rats to hypoxia (7% O2) markedly increased the level of heme oxygenase-1 (HO-1) mRNA in several tissues. Accumulation… 
Highly Cited
1997
Highly Cited
1997
Reduced stress defense in heme oxygenase 1-deficient cells.
Stressed mammalian cells up-regulate heme oxygenase 1 (Hmox1; EC 1.14.99.3), which catabolizes heme to biliverdin, carbon… 
Highly Cited
1996
Highly Cited
1996
Transcriptional activation and chromatin remodeling of the HIV‐1 promoter in response to histone acetylation.
After integration in the host cell genome, the HIV‐1 provirus is packaged into chromatin. A specific chromatin disruption occurs… 
Highly Cited
1995
Highly Cited
1995
The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF
Highly Cited
1994
Highly Cited
1994
Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein.
The p53 tumor suppressor gene product is a transcriptional activator that may be associated with its ability to suppress tumor… 
Highly Cited
1990
Highly Cited
1990
Kappa B-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor alpha gene in primary macrophages
We have explored the cis-acting elements necessary for the LPS-mediated activation of the mouse TNF-alpha promoter by… 
Highly Cited
1989
Highly Cited
1989
CpG methylation of the cAMP-responsive enhancer/promoter sequence TGACGTCA abolishes specific factor binding as well as transcriptional activation.
In mammals and other vertebrates, cytosine methylation in CpG sites is often negatively correlated with gene activity. Because… 
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