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Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
The purification and characterization of an EED-EZH2 complex, the human counterpart of the Drosophila ESC-E(Z) complex, is reported, and it is demonstrated that the complex specifically methylates nucleosomal histone H3 at lysine 27 (H3-K27).
Role of histone H2A ubiquitination in Polycomb silencing
The purification and functional characterization of an E3 ubiquitin ligase complex that is specific for histone H2A is reported, and it is linked to Polycomb silencing, which is important in regulating chromatin dynamics and transcription.
Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification
- Shinsuke Ito, A. D’Alessio, O. Taranova, Kwonho Hong, L. Sowers, Yi Zhang
- Biology, ChemistryNature
- 26 August 2010
It is demonstrated that all three mouse Tet proteins (Tet1, Tet2 and Tet3) can also catalyse a similar reaction, uncover the enzymatic activity of the Tet proteins, and demonstrate a role for Tet1 in ES cell maintenance and inner cell mass cell specification.
Histone demethylation by a family of JmjC domain-containing proteins
The JmjC domain is identified as a novel demethylase signature motif and a protein demethylation mechanism that is conserved from yeast to human is uncovered.
Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing.
JmjC-domain-containing proteins and histone demethylation
The evolutionary relationship between Jumonji C (JmjC)-domain-containing proteins is analysed and their cellular functions in relation to their potential enzymatic activities are discussed.
Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine
This study raises the possibility that DNA demethylation may occur through Tet-catalyzed oxidation followed by decarboxylation, and identifies two previously unknown cytosine derivatives in genomic DNA as the products of Tet proteins.
Role of Histone H3 Lysine 27 Methylation in X Inactivation
It is demonstrated that transient recruitment of the Eed-Ezh2 complex to the inactive X chromosome (Xi) occurs during initiation of X inactivation in both extraembryonic and embryonic cells and is accompanied by H3-K27 methylation.
Hierarchical recruitment of polycomb group silencing complexes.
The diverse functions of histone lysine methylation
Recent advances in understanding of how lysine methylation functions in these diverse biological processes are summarized, and questions that need to be addressed in the future are raised.