Yi Zhang

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Entropy-based Subspace Clustering for Mining Numerical Data
Mining numerical data is a relatively difficult problem in data mining. Clustering is one of the techniques. We consider a database with numerical attributes, in which each transaction is viewed as a multi-dimensional vector. By studying the clusters formed by these vectors, we can discover certain behaviors hidden in the data. Traditional clustering… (More)
Call admission control schemes and performance analysis in wireless mobile networks
Call admission control (CAC) plays a significant role in providing the desired quality of service in wireless networks. Many CAC schemes have been proposed. Analytical results for some performance metrics such as call blocking probabilities are obtained under some specific assumptions. It is observed, however, that due to the mobility, some assumptions may… (More)
New Nomenclature for Chromatin-Modifying Enzymes
In the last ten years, the importance of chromatin modifications in many aspects of biology has become apparent. Several families of enzymes that modify histones have been identified, the majority of which are conserved throughout evolution. The enormous interest in this field has resulted in a very rapid rate of discovery of new enzymes, but this in turn… (More)
Neural origin of spontaneous hemodynamic fluctuations in rats under burst-suppression anesthesia condition.
Spontaneous hemodynamic signals fluctuate coherently within many resting-brain functional networks not only in awake humans and lightly anesthetized primates but also in animals under deep anesthesia characterized by burst-suppression electroencephalogram (EEG) activity and unconsciousness. To understand the neural origin of spontaneous hemodynamic… (More)
Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter.
Ubiquitination of histone H2B catalyzed by Rad6 is required for methylation of histone H3 by COMPASS. We identified Bre1 as the probable E3 for Rad6's role in transcription. Bre1 contains a C3HC4 (RING) finger and is present with Rad6 in a complex. The RING finger of Bre1 is required for ubiquitination of histone H2B, methylation of lysine 4 and 79 of H3… (More)
The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.
The mammalian target of rapamycin (mTOR) protein kinase is a master growth promoter that nucleates two complexes, mTORC1 and mTORC2. Despite the diverse processes controlled by mTOR, few substrates are known. We defined the mTOR-regulated phosphoproteome by quantitative mass spectrometry and characterized the primary sequence motif specificity of mTOR using… (More)
The Dermatomyositis-Specific Autoantigen Mi2 Is a Component of a Complex Containing Histone Deacetylase and Nucleosome Remodeling Activities
Histone acetylation and deacetylation were found to be catalyzed by structurally distinct, multisubunit complexes that mediate, respectively, activation and repression of transcription. ATP-dependent nucleosome remodeling, mediated by different multisubunit complexes, was thought to be involved only in transcription activation. Here we report the isolation… (More)
Energy Efficiency in Telecom Optical Networks
Since the energy crisis and environmental protection are gaining increasing concerns in recent years, new research topics to devise technological solutions for energy conservation are being investigated in many scientific disciplines. Specifically, due to the rapid growth of energy consumption in ICT (Information and Communication Technologies), lot of… (More)
A k-mer scheme to predict piRNAs and characterize locust piRNAs
MOTIVATION Identifying piwi-interacting RNAs (piRNAs) of non-model organisms is a difficult and unsolved problem because piRNAs lack conservative secondary structure motifs and sequence homology in different species. RESULTS In this article, a k-mer scheme is proposed to identify piRNA sequences, relying on the training sets from non-piRNA and piRNA… (More)