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CDK8 gene

Known as: K35, CDK8, Cyclin-Dependent Kinase 8 Gene 
This gene plays a role in transcriptional regulation.
National Institutes of Health

Related topics

Related topics

10 relations
CDK8 protein, humanCell Cycle ControlCyclin-Dependent Kinase 8Homo sapiens

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CDK8 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Downregulation of miR‑138‑5p promotes non‑small cell lung cancer progression by regulating CDK8.
Dysregulation of microRNAs (miRNAs) is frequently observed during cancer development. Aberrant expression of miRNA‑138‑5p (miR… 
2018
2018
NK Cell–Specific CDK8 Deletion Enhances Antitumor Responses
Mice with an NK cell–specific knockout of CDK8 were used to show that loss of CDK8 enhances NK-cell cytotoxicity and tumor… 
2017
2017
Discovery of novel CDK8 inhibitors using multiple crystal structures in docking-based virtual screening.
2017
2017
In Search of Novel CDK8 Inhibitors by Virtual Screening
Aberrant activity of cyclin-dependent kinase (CDK) 8 is implicated in various cancers. While CDK8-targeting anticancer drugs are… 
2017
2017
Studies of CDK 8/19 inhibitors: Discovery of novel and selective CDK8/19 dual inhibitors and elimination of their CYP3A4 time-dependent inhibition potential.
2015
2015
mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC)
In non-alcoholic fatty liver disease (NAFLD) and insulin resistance, hepatic de novo lipogenesis is often elevated, but the… 
Review
2005
Review
2005
Recent advances in the development of selective small molecule inhibitors for cyclin-dependent kinases.
Loss of normal cell cycle regulation is the hallmark of human cancers, and alteration of the components involved in cell cycle… 
Highly Cited
1999
Highly Cited
1999
Changes in cyclin dependent kinase expression and activity accompanying lens fiber cell differentiation.
Previous studies from this laboratory have shown that differentiating lens fiber cells contain two active cyclin dependent… 
Highly Cited
1997
Highly Cited
1997
The human T-cell leukemia virus type 1 transactivator protein Tax colocalizes in unique nuclear structures with NF-kappaB proteins
The Tax protein of human T-cell leukemia virus type 1 (HTLV-1) is a potent activator of viral transcription. Tax also activates… 
Highly Cited
1996
Highly Cited
1996
Drosophila Cdk8, a kinase partner of cyclin C that interacts with the large subunit of RNA polymerase II.
A number of cyclins have been described, most of which act together with their catalytic partners, the cyclin-dependent kinases… 
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