CDK8 gene

Known as: K35, CDK8, Cyclin-Dependent Kinase 8 Gene 
This gene plays a role in transcriptional regulation.
National Institutes of Health

Related topics

Related topics

10 relations
CDK8 protein, humanCell Cycle ControlCyclin-Dependent Kinase 8Homo sapiens
(More)

Narrower (1)

CDK8 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
HIF1A Employs CDK8-Mediator to Stimulate RNAPII Elongation in Response to Hypoxia
The transcription factor HIF1A is a key mediator of the cellular response to hypoxia. Despite the importance of HIF1A in… (More)
  • figure 1
  • figure 2
  • figure 4
  • figure 5
  • figure 6
Is this relevant?
Highly Cited
2013
Highly Cited
2013
A conserved Mediator–CDK8 kinase module association regulates Mediator–RNA polymerase II interaction
The CDK8 kinase module (CKM) is a conserved, dissociable Mediator subcomplex whose component subunits were genetically linked to… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2010
Highly Cited
2010
The histone variant macroH2A suppresses melanoma progression through regulation of CDK8
Cancer is a disease consisting of both genetic and epigenetic changes. Although increasing evidence demonstrates that tumour… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2010
Highly Cited
2010
CDK8 is a positive regulator of transcriptional elongation within the serum response network
The Mediator complex allows communication between transcription factors and RNA polymerase II (RNAPII). Cyclin-dependent kinase 8… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Review
2010
Review
2010
CDK8: a positive regulator of transcription.
CDK8 belongs to a group of cyclin-dependent kinases involved in transcriptional regulation from yeast to mammals. CDK8 associates… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2009
Highly Cited
2009
The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function.
The human CDK8 subcomplex (CDK8, cyclin C, Med12, and Med13) negatively regulates transcription in ways not completely defined… (More)
Is this relevant?
Highly Cited
2009
Highly Cited
2009
The human CDK8 subcomplex is a histone kinase that requires Med12 for activity and can function independently of mediator.
The four proteins CDK8, cyclin C, Med12, and Med13 can associate with Mediator and are presumed to form a stable "CDK8 subcomplex… (More)
Is this relevant?
Highly Cited
2008
Highly Cited
2008
CDK8 is a colorectal cancer oncogene that regulates β-catenin activity
Aberrant activation of the canonical WNT/β-catenin pathway occurs in almost all colorectal cancers and contributes to their… (More)
  • figure 1
  • figure 2
  • table 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2008
Highly Cited
2008
E2F1 represses β-catenin transcription and is antagonized by both pRB and CDK8
The E2F1 transcription factor can promote proliferation or apoptosis when activated, and is a key downstream target of the… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2007
Highly Cited
2007
CDK8 is a stimulus-specific positive coregulator of p53 target genes.
The p53 transcriptional network orchestrates alternative stress responses such as cell-cycle arrest and apoptosis. Here we… (More)
Is this relevant?