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CDK8 gene
Known as:
K35
, CDK8
, Cyclin-Dependent Kinase 8 Gene
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This gene plays a role in transcriptional regulation.
National Institutes of Health
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Related topics
Related topics
10 relations
CDK8 protein, human
Cell Cycle Control
Cyclin-Dependent Kinase 8
Homo sapiens
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Narrower (1)
CDK8 wt Allele
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Downregulation of miR‑138‑5p promotes non‑small cell lung cancer progression by regulating CDK8.
Shigang Xing
,
Qinghua Xu
,
Xinlei Fan
,
Shanxia Wu
,
Feng Tian
Molecular Medicine Reports
2019
Corpus ID: 204834772
Dysregulation of microRNAs (miRNAs) is frequently observed during cancer development. Aberrant expression of miRNA‑138‑5p (miR…
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2018
2018
NK Cell–Specific CDK8 Deletion Enhances Antitumor Responses
A. Witalisz-Siepracka
,
D. Gotthardt
,
+6 authors
V. Sexl
Cancer immunology research
2018
Corpus ID: 4607234
Mice with an NK cell–specific knockout of CDK8 were used to show that loss of CDK8 enhances NK-cell cytotoxicity and tumor…
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2017
2017
Discovery of novel CDK8 inhibitors using multiple crystal structures in docking-based virtual screening.
Taijin Wang
,
Zhuang Yang
,
+5 authors
Lijuan Chen
European journal of medicinal chemistry
2017
Corpus ID: 24777819
2017
2017
In Search of Novel CDK8 Inhibitors by Virtual Screening
Malika Kumarasiri
,
Theodosia Teo
,
+6 authors
Shudong Wang
Journal of Chemical Information and Modeling
2017
Corpus ID: 1686151
Aberrant activity of cyclin-dependent kinase (CDK) 8 is implicated in various cancers. While CDK8-targeting anticancer drugs are…
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2014
2014
MicroRNA-107 promotes proliferation of gastric cancer cells by targeting cyclin dependent kinase 8
Yan-qiang Song
,
Xu-hui Ma
,
+4 authors
Wen-ping Lv
Diagnostic Pathology
2014
Corpus ID: 15889520
BackgroundThe biological processes and molecular mechanisms underlying miR-107 remain unclear in gastric cancer(GC). In this…
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2011
2011
Gene repressive activity of RIP140 through direct interaction with CDK8.
Shawna D. Persaud
,
Wei-Hong Huang
,
Sung Wook Park
,
Li-Na Wei
Molecular Endocrinology
2011
Corpus ID: 33916547
Receptor interacting protein 140 (RIP140) is a coregulator for numerous nuclear receptors and transcription factors and primarily…
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2002
2002
Molecular cloning and characterisation of p15(CDK-BP), a novel CDK-binding protein.
L. Vogel
,
B. Baratte
,
L. Detivaud
,
L. Azzi
,
P. Léopold
,
L. Meijer
Biochimica et Biophysica Acta
2002
Corpus ID: 36030404
Highly Cited
1999
Highly Cited
1999
Changes in cyclin dependent kinase expression and activity accompanying lens fiber cell differentiation.
C. Gao
,
A. Rampalli
,
H. Cai
,
H. Y. He
,
P. Zelenka
Experimental Eye Research
1999
Corpus ID: 25433126
Previous studies from this laboratory have shown that differentiating lens fiber cells contain two active cyclin dependent…
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Highly Cited
1997
Highly Cited
1997
The human T-cell leukemia virus type 1 transactivator protein Tax colocalizes in unique nuclear structures with NF-kappaB proteins
F. Bex
,
A. McDowall
,
A. Burny
,
R. Gaynor
Journal of Virology
1997
Corpus ID: 24801498
The Tax protein of human T-cell leukemia virus type 1 (HTLV-1) is a potent activator of viral transcription. Tax also activates…
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Highly Cited
1996
Highly Cited
1996
Drosophila Cdk8, a kinase partner of cyclin C that interacts with the large subunit of RNA polymerase II.
V. Leclerc
,
J. Tassan
,
P. O’Farrell
,
E. Nigg
,
P. Léopold
Molecular Biology of the Cell
1996
Corpus ID: 45710571
A number of cyclins have been described, most of which act together with their catalytic partners, the cyclin-dependent kinases…
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