• Publications
  • Influence
Cell division: Mitotic kinases as regulators of cell division and its checkpoints
  • E. Nigg
  • Biology, Medicine
  • Nature Reviews Molecular Cell Biology
  • 2001
Mitosis and cytokinesis are undoubtedly the most spectacular parts of the cell cycle. Errors in the choreography of these processes can lead to aneuploidy or genetic instability, fostering cell deathExpand
  • 1,414
  • 94
  • Open Access
Plk4-induced centriole biogenesis in human cells.
We show that overexpression of Polo-like kinase 4 (Plk4) in human cells induces centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parentalExpand
  • 600
  • 78
  • Open Access
Proteomic characterization of the human centrosome by protein correlation profiling
The centrosome is the major microtubule-organizing centre of animal cells and through its influence on the cytoskeleton is involved in cell shape, polarity and motility. It also has a crucialExpand
  • 1,205
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Polo-like kinases and the orchestration of cell division
Polo-like kinases (Plks) are increasingly recognized as key regulators of mitosis, meiosis and cytokinesis. In agreement with a broad range of proposed functions during cell division, Plks areExpand
  • 954
  • 63
Quantitative Phosphoproteomics Reveals Widespread Full Phosphorylation Site Occupancy During Mitosis
Protein phosphorylation during the cell cycle may be an all-or-none process in many instances. All-or-None Phosphorylation Phosphorylation is a key regulatory event that drives many cellularExpand
  • 1,224
  • 61
Cep164, a novel centriole appendage protein required for primary cilium formation
Primary cilia (PC) function as microtubule-based sensory antennae projecting from the surface of many eukaryotic cells. They play important roles in mechano- and chemosensory perception and theirExpand
  • 414
  • 56
  • Open Access
The Polo kinase Plk4 functions in centriole duplication
The human Polo-like kinase 1 (PLK1) and its functional homologues that are present in other eukaryotes have multiple, crucial roles in meiotic and mitotic cell division. By contrast, the functions ofExpand
  • 693
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Role of Hec1 in Spindle Checkpoint Signaling and Kinetochore Recruitment of Mad1/Mad2
The spindle checkpoint delays sister chromatid separation until all chromosomes have undergone bipolar spindle attachment. Checkpoint failure may result in chromosome mis-segregation and mayExpand
  • 461
  • 54
Rootletin forms centriole-associated filaments and functions in centrosome cohesion
After duplication of the centriole pair during S phase, the centrosome functions as a single microtubule-organizing center until the onset of mitosis, when the duplicated centrosomes separate forExpand
  • 312
  • 49
  • Open Access
Centrosome aberrations: cause or consequence of cancer progression?
  • E. Nigg
  • Biology, Medicine
  • Nature Reviews Cancer
  • 1 November 2002
Many human tumours show centrosome aberrations, indicating an underlying deregulation of centrosome structure, duplication or segregation. Centrosomes organize microtubule arrays throughout the cellExpand
  • 734
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