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Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer.
NF-κB comprises a family of inducible transcription factors that serve as important regulators of the host immune and inflammatory response. In addition, NF-κB is also involved in protecting cellsExpand
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Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs.
Human immunodeficiency virus type 1 (HIV-1) gene expression is modulated by both viral and cellular factors. A regulatory element in the HIV-1 long terminal repeat known as TAR, which extends fromExpand
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The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β
NF-κB comprises a family of cellular transcription factors that are involved in the inducible expression of a variety of cellular genes that regulate the inflammatory response,. NF-κB is sequesteredExpand
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The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta.
NF-kappaB comprises a family of cellular transcription factors that are involved in the inducible expression of a variety of cellular genes that regulate the inflammatory response. NF-kappaB isExpand
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Domains in the SPT5 Protein That Modulate Its Transcriptional Regulatory Properties
ABSTRACT SPT5 and its binding partner SPT4 regulate transcriptional elongation by RNA polymerase II. SPT4 and SPT5 are involved in both 5,6-dichloro-1-β-d-ribofuranosylbenzimidazole (DRB)-mediatedExpand
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Histone H3 phosphorylation by IKK-α is critical for cytokine-induced gene expression
Cytokine-induced activation of the IκB kinases (IKK) IKK-α and IKK-β is a key step involved in the activation of the NF-κB pathway. Gene-disruption studies of the murine IKK genes have shown thatExpand
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Role of the TAB2‐related protein TAB3 in IL‐1 and TNF signaling
The cytokines IL‐1 and TNF induce expression of a series of genes that regulate inflammation through activation of NF‐κB signal transduction pathways. TAK1, a MAPKKK, is critical for both IL‐1‐ andExpand
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IkappaB kinases: key regulators of the NF-kappaB pathway.
The nuclear factor (NF)-kappaB pathway is important for the expression of a wide variety of genes that are involved in the control of the host immune and inflammatory response, and in the regulationExpand
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Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression.
Cytokine-induced activation of the IkappaB kinases (IKK) IKK-alpha and IKK-beta is a key step involved in the activation of the NF-kappaB pathway. Gene-disruption studies of the murine IKK genes haveExpand
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