Actin Dynamics Control SRF Activity by Regulation of Its Coactivator MAL
The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF
Nuclear Actin Regulates Dynamic Subcellular Localization and Activity of the SRF Cofactor MAL
A function of nuclear actin is reported in the regulation of MAL, a coactivator of the transcription factor serum response factor (SRF), and fluorescence resonance energy transfer analysis demonstrates that the MAL-actin interaction responds to extracellular signals.
Regulation of transcription by MAP kinase cascades.
- R. Treisman
- Biology, Computer ScienceCurrent Opinion in Cell Biology
- 1 April 1996
The POZ domain: a conserved protein-protein interaction motif.
A novel zinc finger protein, ZID, which contains a 120-amino-acid conserved motif present in a large family of proteins that includes both the otherwise unrelated zinc finger proteins and a group of poxvirus proteins, is described.
Signal-Regulated Activation of Serum Response Factor Is Mediated by Changes in Actin Dynamics
Transcriptional Regulation by Extracellular signals: Mechanisms and Specificity
Rho-actin signaling to the MRTF coactivators dominates the immediate transcriptional response to serum in fibroblasts
The role of the SRF network in the fibroblast serum response is investigated and a critical role for MRTF signaling is demonstrated, underpinning the role of SRF in the cellular response to mechanical cues.
Human SRF-related proteins: DNA-binding properties and potential regulatory targets.
RSRF-binding sites are found in the regulatory sequences of a number of growth factor-inducible and muscle-specific genes, and it is shown that RSRF polypeptides are components of previously characterized binding activities that interact with these elements.